Barely Significant
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“may be significant”

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In addition, the detrimental effects of recurrent short courses of oral corticosteroids may be significant. 5 6 7 8 It seems sensible that if a child of school age has experienced repeated episodes of acute asthma that resulted in health resource use, the parent should be advised to keep oral corticosteroids available to be used in the event of a relatively severe episode.
The efficacy and safety of immunotherapy with DPCP in pediatric alopecia areata has been well documented.[ 5 ] CONCLUSION We report the association of alopecia areata with a rare genetic syndrome-BPES, which may be significant considering the surfacing evidence on the genetic basis of alopecia areata.
Thermodynamic aspects of complex coacervation have been covered extensively by others, 7 − 18 to which we refer the interested reader for a more in-depth description. Briefly, both enthalpic and entropic contributions may be significant, each of which depends markedly on the ionic strength of the solution.
It is possible that UCN-01 inhibits CAK indirectly. One may speculate that CDK inhibitor proteins induced by UCN-01 bind to the inactive form of CDK2 and prevent its phosphorylation by CAK.34) We cannot exclude the alternative possibility that UCN-01 promotes the degrada- tion of Thr160-phosphorylated CDK2 protein by an as yet unknown mechanism. Our data suggest that the contribution of the p27Kip1 pro- tein to the CDK2 inhibition by treatment with UCN-01 may be significant in the WiDr and Saos-2 cell lines (Fig. 3).