“may be significant”

The apparent contrast between the present study and earlier findings [ 43 ] [ 45 ] may thus suggest that metformin acts (1) on GLP-1 secretion independently of AMPK, as recently reported in studies of hepatic gluconeogenesis [ 47 ], or (2) that there may be significant differences between the impact of acute and chronic activation of L-cell AMPK on a “gut-brain-liver axis”, with the latter acting chiefly to alter cell mass.

Finally, most of the studies included in this systematic review were conducted in developing countries, with only three in developed countries, so there may be significant research gaps between countries or regions. 7 Conclusions This review identifies key barriers and facilitators to cervical cancer screening among WLWH, including individual factors (risk perception, understanding of health, family responsibilities, trust in HIV care), systemic barriers (symptom burden, fear, privacy concerns, gaps in knowledge, negative healthcare experiences, financial, and logistical constraints), and social factors (stigma, socioeconomic status).

In elderly patients on a sodium-depleted diet, a drop in GFR may be significant after a single dose of COX-2 inhibitor [ 9 ].

In summary, applying Fe NO50 in daily asthma self-monitoring may be significant for asthma management.

This difference may be significant in the scope of biotechnological applications, potentially leading to reduction of overall time needed to achieve the same result.

These findings suggest that independent of socioeconomic or environmental factors, there may be significant variations in the underlying tumor biology and differential mechanisms by which endometrial cancer propagates.

An important area that may be significant in both the long-term treatment and prevention of diabetes is the use of supplemental micronutrients, as diabetic patients are often deficient in B vitamins and micronutrients, such as chromium, zinc, and selenium[ 14 - 16 ].

Conclusion Although the impact of the new guidance is difficult to quantify among the overall infant population, the impact may be significant for this small, high-risk population, which, after having incurred high costs for birth hospitalization [ 19 ], will potentially be at risk for additional adverse outcomes such as RSV hospitalization, intensive care admission, and mechanical ventilation.

Within contemporary society, the role of perceived social support may be significant in facilitating individuals’ engagement with eHealth resources, thereby enhancing their eHealth literacy [ 9 ].

Furthermore, KEGG pathway analysis suggests that the HIF-1 signaling pathway may be significant in the identified network, supporting the hypothesis that BB could be used to treat diabetes.

6.2 Mixtures of anthropogenic pollutants and desert dust In addition to the mineral matter (typically the dominant PM component during dust outbreaks), the anthropogenic PM contribution may be significant.

As most participants in the present meta-analysis were drawn from the general population, the effect of early-life antibiotic exposure may be significant only against specific genetic backgrounds, such as in carriers of high-risk HLA genes, whereas its impact is diluted in unselected populations.

It is suspected that mechanisms related to dissociative disorders may be significant to the negative outcomes of early traumatic events.

This implies that social capital, especially in terms of trust, social connection, and social participation may be significant for alleviating loneliness in later life.

As such, there may be significant benefits from exercise in individuals with T2D and metabolic disease outside of those that are induced due to weight loss alone.

The high cephalic spread of ropivacaine analgesia may be significant but still its quality may not correlate with the level of sensory analgesia.[ 13 ] The addition of clonidine as an adjuvant allows a lesser dose of ropivacaine when used intrathecally for cesarean section.[ 14 ] Clonidine augments the action of local anesthetics in regional blockades by interrupting the neural transmission of painful stimuli in Aδ and C fibres as well as augments the blockade of local anesthetic agents by increasing the conductance of K + ions in nerve fibres.

While the challenges presented may be significant, they embody the standard hurdles of medical device production and validation that will be mitigated as research continues. 4.

Laboratory findings may be significant for hyponatremia, elevated erythrocyte sediment rate and C-reactive protein, hypophosphatemia, elevated ferritin, microscopic hematuria, and elevated liver enzymes.

These findings suggest that granule ultrastructure, not just chemical composition, may be significant in producing the range of colors presented in cephalopod chromatophores.

However, certain microbial metabolites have been shown to be detrimental to health and may be significant contributors to the development and progression of metabolic diseases in the host [ 97 ].

It may be significant that the second affected sibling died of respiratory failure.

For example, the plasmaspheric contribution to GPS-TEC may be significant particularly during geomagnetic storm.

The similar result showed in testing of mood, positive mood may be significant in older adults, helping individuals to satisfy with themselves and others, living better in the final stage of their lives [ 41 ].

While the reported associations may be significant, they do not directly imply causality.

It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.