“may be significant”

7 - 10 Current methods of assessing kidneys rely on donor history and visual inspection, yet even strongly predictive factors signify cohort rather than individual risk, and there may be significant intracohort variability in outcomes. 6 , 9 , 11 - 15 Similarly, the relationship between the macroscopic appearance and transplant outcomes remains ill-defined. 16 , 17 Quality assessment technologies, such as histopathological analysis or machine perfusion, may aid in organ selection by providing an additional, individualized data point.

Environmental factors, such as exposure to various pollutants, may be significant risk factors for both asthma and DED, however they were not evaluated in this study.

20 , 21 While the absolute difference in surgical wait times between patients in our three time cohorts is small (approximately 1 week) and unlikely to affect oncologic outcomes, this difference in time may be significant from a patient perspective.

Studies have also shown increased immunogenicity in STS with the use of RT, however, there may be significant biological heterogeneity with regard to immunogenicity and radiosensitivity between DDLPS and other histologies, and additional prospective data will help elucidate more nuanced pathologic response and survival differences for patients undergoing combination NIT/RT [ 34 , 35 ].

While some models neglect these effects, 4 , 15 , 16 , 32 , 33 they may be significant in certain applications.

Viral load, early intervention, gender, blood groups, comorbidities, and inherited genotypic variants may be significant variables (Vetter et al. 2020 ; Wu et al. 2021 ; van der Made et al. 2020 ).

Lapidus Several studies corroborate that first metatarsal shortening may be significant with the Lapidus procedure. 28 , 29 This was dependent on the method used to prepare the tarsometatarsal joint for fusion, with some estimates as high as 7.5 mm with osseous resection and 5.0 mm with curettage. 17 , 30 , 31 To mitigate this, Hatch et al 30 describe the use of a cutting jig to enable precise resection of the first tarsometatarsal joint surfaces, yielding promising results and reducing the mean first metatarsal shortening to 3.1 mm.

Because recessive deleterious mutations can be hidden in the heterozygous state, they may be significant to the evolutionary fate of populations.

This high level of training background means that there may be significant differences in their motor skills, body control, and motor coping abilities, which is crucial for the interpretation of the results of the study of the effects of fatigue and anticipation on their motor performance.

In both regimes (cryogenic temperatures and close to RT), the observed lifetime shifts may be significant enough to have potential applications in ROT.

Therefore, there may be significant publishing deviations. 4.

From an operational perspective, the challenges may be significant, ensuring sufficient coverage of the first three or required initial number of doses of the vaccine.

Firstly, there may be significant differences in the outcome and safety of cabozantinib in real-life use compared to trial settings.

Several studies provide increasing evidence that such variable Aβ peptides may be significant in AD pathogenesis [ 6 – 9 ].

However, due to the scarcity of studies assessing the association of PhA and OH with physical function in PD, the results may be significant for PD patients.

The demonstrated LL-37 association with cholesterol in our study may be significant in its indirect relationship to disease activity and requires further investigation.

It may be significant that, as shown in the PONDR ® plot in Fig. 6 , the A3 epitope that is capable of inducing spreading and autoimmune disease like the EBNA1 epitope shown in Fig. 5 , is in a strongly ordered region located adjacent to regions of strong disorder of the PONDR ® plot.

Autoimmune diseases have a strong genetic component and the adjustment for parental rheumatoid arthritis suggests that the increase in the odds of disease development in relation to a gene-environment interaction may be significant.

As far as the residents are concerned, in the Lin’an area, there may be significant differences in the quality of recreation between urban areas and rural areas.

The distinct effect of astaxanthin on various NMDA receptor subunits may be significant in facilitating prolonged neuroprotection against high glutamate levels in people with neurological or psychiatric disorders.

The constant phase shift allows phase to be modulated independently of frequency, which may be significant for the interaction of neocortical neurons with slow oscillatory frequencies in the brain 49 .

Since the AKR inhibitor 5β-cholanic acid is a well-tolerated naturally occurring bile acid in humans, and since flufenamic acid has been used in clinical trials with manageable toxicities [ 41 ], there may be significant value in conducting clinical trials in which either 5β-cholanic acid or flufenamic acid are co-administered with doxorubicin during chemotherapy.

The extent of this exposure may be significant, but it is difficult for subjects to recall adequately (10,75).

Although there may be significant upfront costs associated with the development and implementation of epigenetic interventions, advancements in technology, regulatory processes, and healthcare delivery models can help improve the financial feasibility and ensure that treatment outcomes are affordable for the general population in the long term.

It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.