“may be significant”

We discuss areas of controversy and areas requiring further investigation, and we propose that there may be significant plasticity in cellular origins that depends on the context and the oncogenic drivers of HCC.

Thus, it is intriguing to hypothesize that there may be significant cross-talk between GSK3 and EGFR signaling pathways.

This illustrates that there may be significant structural differences even within each NA serotype and highlights the importance of the structural analysis of novel NA proteins like N9 from H7N9.

These results suggest that, despite the majority of the population is expected to contract the infection in the long run, there may be significant differences between remote and on-site workers in terms of infection probability over a shorter time period.

Some loss to follow-up is unavoidable, and in a 2-year follow-up of a mixed group of newborn infants, this may be significant.

This possible mechanism has received relatively little attention in the research on social attention and social motivation and ASD, but may be significant nonetheless.

[ 76 ] showed that inhibition of Wnt signaling gastruloids generated using activin A and FGF2 resulted in significant degree of anterior–posterior patterning and suggested that there may be significant compensatory mechanisms for generating a patterned axis, a feature that also bestows enhanced early plasticity.

Economic losses, human morbidity and mortality may be significant during epidemics.

These include vital signs (temperature, blood pressure, and oxygen saturation) or symptoms (cough and shortness of breath); these factors may be significant indicators of COVID-19 severity and of subsequently mortality.

The data suggests a linkage between tau and APP trafficking, which may be significant in Alzheimer's disease.

Therefore, there may be significant differences between the backgrounds of students at MSIs and non-MSIs, which could lead to a potential endogeneity problem when a regression model is used directly.

The zwitterionic nature of this S-MGB, and thus lower logP, may be significant in the observed potency towards Acanthamoeba castellanii , as a comparison of S-MGB-241, 36 , with its methyl ester analogue, S-MGB-238, 30 , reveals the latter to have no measurable activity against A. castellanii .

Second, extending the expression of class B MADS box genes, PaAP3-1 and PaPI-1 , in the sepal may be significant for tepal formation.

Recent research indicates that epigenetic mechanisms, such as the regulation of gene expression by miRNAs, may be significant to AMD in addition to environmental and genetic variables, offering a promising new direction for therapy and research ( Berber et al., 2017 ).

On Mars, the effects of any electrical conductivity enhancement are likely small, but on Titan they may be significant.

On these bases, our demonstration of a further case may be significant in order to highlight a diagnostic approach to intestinal metastatic melanoma, since clinicians should be aware of this rare, but potential endoscopic picture for two main reasons.

This phenomenon may be significant in COVID-19 pathogenesis, as elevated VEGFA levels have been observed in the lungs of deceased COVID-19 patients ( Ackermann et al., 2020 ).

The high GC content may be significant because of two reasons ‐ firstly the higher GC ratio gives a higher chance of complementarities with the coding regions also having a higher GC ratio, secondly since GC pair is bound by 3 hydrogen bonds, these bonds are more stable, so the miRNA binding and degradation of the target genes may be more probable.

Consequently, polymorphisms within the IL-1 gene—particularly the variable number of tandem repeats (VNTR) polymorphism of IL-1Ra—may be significant for donor selection and could contribute to optimizing GVHD prophylaxis and therapeutic outcomes [ 30 ].

The effect of water layers and water-filled nanoblisters on the contraction of graphene at the graphene–mica interface may be significant, lowering the T S to the annealing temperatures applied herein.

Observed differences in cIMT may be significant as early as 8 years of age between children with FH and their unaffected siblings. 16 A 20-year follow-up study of statin therapy in children confirmed the long-term efficacy of early initiation of lipid-lowering therapy by reporting a slowed progression of cIMT and decreased risk of CVD in adultho

This points to IgE-mediated cascades with potential to activate immune stroma and may be significant in the clinical development of strategies targeting tumour-resident macrophages.

Therefore, we demonstrated that CAR may be significant predictors for disease activity in POD patients.

Even if the difference between the velocity may be significant for mixtures containing components with large differences in the molecular weight (in our systems carbon dioxide (MW 44) and hydrogen (MW 2)), it is likely that the errors are of the same order of magnitude of the uncertainties in the evaluation of the dispersion coefficients.

It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.