“may be significant”

In this context, it may be significant that the SHP2 (and SHP1) must be bound to their receptors to derepress phosphatase activity, while SHIP1 does not.

Although hakai-2 does not show root hair phenotypic changes, the methylation changes in relation to root hair development may be significant, as the HIZ1 overexpressor shows increased root hair length and density in response to NPA treatment in a HAKAI-dependent manner.

Results and Discussion We numerically simulate the proposed model and the results demonstrate new phenomena in bifurcation diagram which may be significant to correlate with various experimental situations.

While an OSM-dependent action of osteoclasts and macrophages may be significant for MSC recruitment it is unlikely to explain how bone formation is stimulated by osteoclast-initiated remodelling unless other factors either direct MSC to the site of osteoclast activity or provide an amplifying co-stimulus for OSM action.

However, further studies on the extent of the formation of crystalline H 3 BO 3 in the jadarite system should be considered prior to scale-up, as environmental implications and health effects of H 3 BO 3 may be significant ( Hadrup et al., 2021 ).

In fact, as a result of a strong amplitude covariation, the coherence of two signals may be significant even when the phase covariation is not. 29 In summary, in this work, we have designed an ad hoc method, tailored to our CHS protocol, in order to investigate the level of coherence and phase synchronization between ABP and cerebral total hemoglobin concentration.

Regulation of the miR-200 family by SNAIL also plays a role in vasculogenesis and may be significant both in malignant cancer and in early developing embryos [ 159 ].

Given that these chemicals are ubiquitous, the population health burden may be significant if the associations were causal. status released display-pdf yes is-in-collection-domain yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Issue date 2014 Apr.

( 59 ) AAV treatments commonly give rise to a range of adverse effects that, although minor in a medical context, may be significant from the patient’s perspective.

The tendency of IgAN to be diagnosed at later CKD stages in the United States suggests that kidney damage may be significant before treatment can begin, implying the need for increased awareness and urine screening for proteinuria.

Among postpartum women who remain depressed, there may be significant interactions between the effects of antidepressant use and exogenous oxytocin on neural activity associated with processing emotional information.

Preclinical data suggests that anti-PD-1 therapy and radiotherapy are best given concurrently, as there may be significant synergy between these two therapies [ 50 , 51 ].

Identifying myelitis of otherwise unknown origin and the detection of anti-NAE antibodies may be significant in the diagnosis.

Although MI is relatively inexpensive, continued training and supervision of providers may be significant expenses.

Thus, our results show there may be significant populations of smallholder farmers in Africa that rely on little to no NTFP resources.

This behavioral effect of introgression may be significant for salmonids, since local adaptations are common and the “optimal behavior” can vary greatly between populations 8 , 18 .

Further testing of Nox4 and AKT inhibitors (downstream of mTOR) or AMPK and Sirt1 activators (which regulate mTOR) may be significant for regulating mTOR and treating certain symptoms of CMDs.

These results suggest that the signaling pathway “Role of Cytokines in Mediating Communication between Immune Cells” may be significant in ESRD progression.

Currently, acetone and lipid peroxidation products have been seen in small scale studies, though other compounds may be significant.

Theoretically, traffic load and vehicle density data may be significant indicators that reflect vehicle exhaust emissions during a short period of time.

A 2012 Australian-based case-control study 20 suggests that concomitant sodium valproate administration (odds ratio: 2.59) and rapid dose escalation (odds ratio: 1.26) may be significant risk factors for CIM development.

Beyond the pathogenesis of cardiovascular diseases, these findings may be significant to all fields of inflammaging.

This disparity may be significant in clinical decision-making, potentially impacting on patient postoperative experience and satisfaction—a symptom highly valued by both surgeons and patients.

Given the known association between P5B ATPase function and Parkinsons disease, it may be significant that the human ortholog of vab-3 is Pax6, which has been shown to be important for dopaminergic neuron survival [ 53 ].

28) Rarely, the degree of tracheal compression may be significant, leading to clinical symptoms and resulting in innominate artery compression syndrome. 29) In this condition, further assessment with cross-sectional imaging (CT or MRI) should be performed to delineate associated arch anomalies.