All p -values reported as p <0.001, indicating statistical significance of AUCs for discrimination, except for poor performing markers, which may be significant due to group imbalance or distribution skew.
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In the literature
Therefore, our findings on the effects of perceived support may be significant for the reduction of depressive symptoms during the COVID-19 pandemic, in which prevention is heavily focused on social distancing.
This may be significant because a general tendency exists that smaller BW leads to more severe outcome.
36 This combination may be significant to patients’ concurrent use of medications and appropriateness of treatment management.
6) Clinical features are not characteristic, and for this reason delay in diagnosis and management may be significant. 4) Misdiagnosis has been reported in patients suffering from this malignancy. 5) In such cases, reoperation is often unavoidable in order to achieve wide tumor-free margins in the setting of a previously contaminated surgical “bed.” 5) There have been reports of misdiagnosed SS in the knee, 2 6 7) but none in the context of total knee arthroplasty.
The 6-minute delay in delivery of shock may be significant in achieving ROSC.
The wide range of settings that could host SHVs indicates that their global extent may be significant and estimates from a large dataset of vent fields suggest that between 15 and 20% of all vent fields host some degree of sediment hydrothermalism.
It may be significant that the voltage dependence was low (eofold/42 mV) in the relatively direct experiments in which inactivation was removed proteoly- tically (Fig. 10 of Horn et al., 1984).
Therefore, developing drugs that target the distal enhancer sequence or regulatory process may be significant for treating some diseases that involves overexpression of IFNβ.
This supported previous research which suggested that lack of face-to-face interactions and established relationships between GPs and community pharmacists may be significant barriers to collaboration [ 12 ].
These reflections need qualifying by mention of some obvious limitations of the present research, the first being that it is wholly observational: it offers no way of separating correlation from causation, so there may be significant confounding factors (such as severity of illness, or motivation for recovery) at play in the results.
Nevertheless, the results presented here suggest that the reactivity of CeO 2 is not limited to well-known dephosphorylation reactions but may also apply to molecules containing sulfonamide or even sulfonyl (and similar) functional groups, which may be significant for both heterogeneous catalysis and environmentally important degradation reactions.
The joint behavior of functionally or spatially related genes may be significant, whereas the activity of individual genes may not.
More than 5 mitotic rates per 10 HPF have been considered as high grade tumor as single mitotic figure may be significant in a tumor with hypercellularity and nuclear atypia [ 13 ].
PM concentrations may not be as high as they traditionally report from industrial worksites, however, the levels may be significant to increase the risk of respiratory and cardiovascular diseases, such as COPD.
Even when insurance coverage exists, there may be significant out-of-pocket costs and access issues.
In such an environment, the economic cost to individuals and businesses may be significant, which in turn demands consideration of development of support systems and compensation systems for those affected. 54 In the USA, a great deal of work has been done on strengthening the public health laws, both generally and specifically for public health emergencies.
[ 4 ] Studies have shown that social anxiety disorder is a combination of physiological, psychological and social factors, and academic pressure, peer influence, family structure and other factors may be significant predictors of social anxiety disorder among adolescents.
As healthcare providers promoting self-management by HIV-positive individuals of both genders, it is important to consider that there may be significant differences between them.
In agreement with our findings, CD8+ T-cells were also found to be mainly directed toward the NP ( 52 ) indicating that this type of response may be significant for long-term disease protection.
This important observation suggests that there may be significant merits in systematically combining AF2 modelling information with sequence data when estimating phylogenetic tree reliability.
This can bring about central nervous system glial cell activation, the generation of pro-inflammatory signaling molecules, and oxidative stress, which may be significant mechanisms contributing to the neurodegenerative process in PD [ 17 ].
End-Stage Renal Disease Patients on dialysis for ESRD are particularly susceptible to infection with COVID-19 due to multiple factors.[ 22 ] In addition to highly prevalent comorbidities like diabetes, hypertension, and cardiovascular disease increasing susceptibility, increased exposure during travel to the dialysis centre 3 times per week, and during the dialysis procedure, may be significant factors.
The global fetal impact may be significant if the ARA II is continued beyond the first trimester.
Naturally, we suspect that there may be significant heterogeneity in Npas4 expression dynamics across the POMC population as well.