Barely Significant
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“may be significant”

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In the literature

Role: Co-I RO1 ES016348 Mitsumoto (PI) 07/22/2009 – 04/30/2014 NIH Multicenter ALS Study Cohort Study of Oxidative Stress and Disease Progression The goal of this study is to look at oxidative stress factors on subjects with ALS and determine what stress factors may be significant in the course of the disease.
For example, the transposon library may not be completely saturated, the transposon may not be able to insert itself at a particular genomic region due to secondary structure and the genetic location of the gene may be significant (if a gene is situated in an operon upstream of essential genes then this gene will not be disrupted although may not itself be essential). fadB3 is in an operon with putative essential genes upstream but only non-essential genes downstream. echA5 is the last gene of an operon with a putative essential gene upstream, so it is unclear as to why a transposon mutant was not obtained for these genes.
This may be significant since there is increasing evidence that the integrity of the sperm chromatin at the actual time of fertilization influences embryo survival [ 9 ]; poor sperm DNA integrity may account for some of the infertility commonly thought to lie with mares.
Lim [40] demonstrated that the expression of GSTM2 in the ovary may be significant in protecting oocytes from toxic substances and the decrease in mRNA expression of the cytosolic antioxidant GSTM2 is involved in ovarian oxidative damage to lipids, proteins, DNA, and other cellular components vital for maintaining ovarian function and fertility.