Role: Co-I RO1 ES016348 Mitsumoto (PI) 07/22/2009 – 04/30/2014 NIH Multicenter ALS Study Cohort Study of Oxidative Stress and Disease Progression The goal of this study is to look at oxidative stress factors on subjects with ALS and determine what stress factors may be significant in the course of the disease.
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“may be significant”
In the literature
These enzymatic activities may be significant in the englacial environment, where the OM contribution from the surface is highly dependent on meltwaters and shows strong seasonal variability.
However, effect sizes were larger in women and may be significant with larger sample sizes.
High levels of energy and mental resilience during work in this context, and during health crises in general, may be significant protective factors against burnout.
For example, the transposon library may not be completely saturated, the transposon may not be able to insert itself at a particular genomic region due to secondary structure and the genetic location of the gene may be significant (if a gene is situated in an operon upstream of essential genes then this gene will not be disrupted although may not itself be essential). fadB3 is in an operon with putative essential genes upstream but only non-essential genes downstream. echA5 is the last gene of an operon with a putative essential gene upstream, so it is unclear as to why a transposon mutant was not obtained for these genes.
Timely detection of cytokine storm and appropriate regulation of inflammatory response may be significant in the prevention and treatment of sepsis.
However, if the conditions for salt ion transfer are not so favorable, and the feed solution concentration is lower, the WS in the depleted solution may be significant.
Third, the clinical implications of daily administration of neuromuscular blockade and sedating medications for DP measurement may be significant and should not be overlooked.
This may be significant since there is increasing evidence that the integrity of the sperm chromatin at the actual time of fertilization influences embryo survival [ 9 ]; poor sperm DNA integrity may account for some of the infertility commonly thought to lie with mares.
In this work, we report that the protective effect of baricitinib against death is most pronounced in obese patients which may be significant to immunopathogenesis considerations and therapy selection for disease.
Ideally, all patients identified as at risk should be assessed by a dietitian, although there may be significant resource implications if hospital dietitians are primarily focused on in-hospital patients.
(2020a) correspond to those of this study, indicating an interesting possibility that the moderating effect of gender may be significant if the sample size is expanded.
Thus, in the presented case, low sIgE values (<0.35 kU/L) to allergen components may be significant with regard to future allergies.
harveyi promotes the occurrence of vibriosis, and there may be significant differences in the intestinal barrier function between the resistant and susceptible individuals. 4.2.
Among participants, 65% ( N = 30) were women and 33% ( N = 15) were men, which may be significant as research has shown that more women than men tend to collaborate in interdisciplinary projects ( 22 , 23 ). 4.2.
Lim [40] demonstrated that the expression of GSTM2 in the ovary may be significant in protecting oocytes from toxic substances and the decrease in mRNA expression of the cytosolic antioxidant GSTM2 is involved in ovarian oxidative damage to lipids, proteins, DNA, and other cellular components vital for maintaining ovarian function and fertility.
The unique distributions of chaperones may be significant in such protein folding pathologies.
There may be significant individual anatomic variability affecting the magnitude and distribution of cortical electric fields, and age effects may not be linear through the 8 to 12 year old window we chose to study.
There may be significant differences between patients who have maintained underweight consistently, and those who experienced substantial loss of body weight.
The high ionic conductivity of these phases, in combination with electronic conductivity, may be significant for the generation of the unusual non-dipolar, non-axisymmetric magnetic fields of Uranus and Neptune 8 , 9 .
These reports show that the role of ADAM family proteins in the pathogenesis of metabolic-dependent cancers, such as CRC, may be significant.
HEIDI results indicated that 10 of the 37 genes may be significant due to linkage disequilibrium, while 27 were consistent with pleiotropy or causal relationships (Supplementary Table S1 in S1 File ).
An indirect effect ab may be significant, even when a or b in itself are not (Hayes, 2013 ).
We selected the filtering threshold of |logFC| > 0.5 and p < 0.05 to maximize the inclusion of potential DEGs during preliminary screening, allowing us to detect subtle gene expression changes that may be significant in ischemic stroke pathophysiology.
Naturally, we suspect that there may be significant heterogeneity in Npas4 expression dynamics across the POMC population as well.