“may be significant”

It is also worth noting that the analysis of changes in the values of hemorheological parameters, such as aggregability of erythrocytes and plasma viscosity, may be significant because thromboembolic events may be the cause of complications in the process of surgical and chemotherapeutic treatments of cancer.

Nevertheless, in this context, the additional copy of the PPP1R13L gene observed in samples from the European population may be significant for the progression of liver injury and the severity of CHC.

Our results indicate that fluorochemical manufacturers may be significant sources of BPAF and its homolog.

Therefore, the risk of NIHL and other chronic conditions in cumulative exposures to noise in OHNS OR may be significant and future studies should continue to elucidate this occupational hazard.

The time-period over which the tissue freezes is an important consideration as damage due to ice-crystal formation may be significant, thus altering the level of cellular or sub-cellular detail that can be preserved in the sample.

Conclusions: Preoperative ALP, preoperative iPTH, and Δphosphorus at 48 hours may be significant factors in estimating the postoperative calcium requirement.

The relatively low threshold of 43.32 suggests that even slight elevations in ALP may be significant in detecting liver damage.

Finally, manual segmentation of ROI is both tedious and time consuming, and there may be significant variability among different observers.

Thus, when seeking for candidates for prognostic biomarkers and therapeutic targets, it is necessary to consider that there may be significant differences between the gene profiles of PDAC primary tumors and metastatic colony-forming PDAC tumors.

With regards to tumour tissue processing methods, the use of fresh frozen (FF) samples for tumour tissue instead of formalin-fixed paraffin-embedded (FFPE) marginally increased from 57.1% to 66.7%, suggesting fragmentation of DNA in FFPE processing may be significant, especially when the detection assay relies on amplicon-based amplification [ 72 , 100 , 148 ]. 3.4.

However, using objective methods to monitor ST, such as accelerometers, otherwise known as wearable activity monitors, helps to minimize self-report bias and allows for examination of sedentary bout patterns as they occur in the free-living environment, which may be significant contributors to certain health outcomes.

It follows that changing the anchor may change the ultimate identification of specific MSDs for PRO measures, which in some cases, may be significant enough to change the downstream interpretation of scores and decision-making based on those scores [ 6 ].

Since the in vivo infusion of ANG III increased plasma aldosterone concentration without increasing blood pressure, ANG III may be significant for the pathophysiological part of aldosterone breakthrough through the induction of aldosterone release. 5.

According to the current literature, instead of a single protein such as p53 or HBx being the crucial factor governing the differences between the HepG2 and Hep3B cell lines, the different origins of biopsy specimens and multiple related factors may be significant.

In the absence of transparency, there may be significant risks of employees in an all remote setting forming inaccurate and perhaps unfavorable beliefs about what others are being paid (e.g., Nai et al. 2020 ) since there is no natural “corridor gossip”. 6 GitLab members were clear that they are all remote, not flat.

The overall effect size on eGFR was relatively modest in both studies, suggesting that firstly patients were required to be on the drug for long periods of time to gain the most benefit and secondly that there may be significant variance in response rates to tolvaptan.

In one study, it was shown that metal ions can alter the monocyte metabolism and thus may be significant to monocyte function [ 24 ].

2 The shape of the cesarean scar by ultrasound may be significant, but there is limited proof to correlate the appearance of the scar with the function.

While there may be significant benefits to identifying genetically beneficial products or genetic determinants of disease, there are also concerns about altering natural environments and about collecting routine genetic information from general populations [ 7 ].

The function of hyperoxidized 2CP as a chaperone may be significant but hardly explains the physiological advantage of the delicate dimer-oligomer-multimer equilibria of the reduced form with far less chaperone activity ( Jang et al., 2004 ; König et al., 2003 ).

This sequence would be expected to occur randomly once every 4 5 bp, or about 1 in 1000 nt, and so it may be significant that it is found three times in the first 100 nt of 7SK.

Notably, this study revealed that although MFCs might appear macroscopically similar and may obtain an identical macroscopic grading, the histological difference between such changes may be significant, ranging from the presence of occasional pigmented cells dispersed between seemingly unaffected myocytes to severe granulomatous inflammatory changes with abundant presence of melanised cells.

The head or neck region of the animal is usually firmly restrained and re- sultant stress to the animal may be significant.

If sleep disorders go undiagnosed, the negative impact on daytime functioning may be significant [ 64 , 98 – 101 ].

Naturally, we suspect that there may be significant heterogeneity in Npas4 expression dynamics across the POMC population as well.