Barely Significant
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“may be significant”

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In the literature

Particularly in cases where metagenomics informs differential diagnosis where the cause of encephalitis may be either autoimmune or infective, the value of metagenomics in helping clinicians avoid starting inappropriate treatment may be significant, for example where steroids would worsen the morbidity related to viral encephalisti.
Clinical metagenomics: ethical issues.
J Med Microbiol · 2025 · PMC11868657
For example, there may be significant differences in genetic background, lifestyle, and environmental exposure levels among different individuals, and these factors may interact with the effects of TPHP and jointly influence the risk of GBM occurrence.