“may be significant”

Similarly, the European Food Safety Authority established a threshold value for acute toxicity at 20 μg/kg body weight, emphasizing that even low levels of exposure may be significant, particularly in sensitive individuals [ 20 ].

The impact of this nematode may be significant both for wildlife and domestic animals, as it can cause severe eye damage including keratitis, corneal opacity, and/or ulceration, which combined with mechanical injury and secondary infections of the eye may result in sight impairment or sight loss [ 101 ].

Furthermore, since there may be significant differences in lipid metabolism and insulin resistance among different ethnic groups ( 45 ), the conclusions of this study have limitations when applied across different ethnic groups.

Our finding that retinal-loukomasomes colocalize with MAP2 may be significant as MAPs may alter the ability of microtubules to form loops in at least a couple of different ways.

Furthermore, there may be significant and as yet unmeasured variables that effect the CH measurement.

Tollip is potentially more potent in polyQ clearance than p62 in HeLa cells is, suggesting that Tollip, also implicated in innate immunity, may be significant for human health and disease through its function as an aggrephagy receptor [ 80 ].

54 There may be significant differences in the composition and functional status of the tumor microenvironment related to different types of tumors, intrinsic characteristics of tumors, tumor stages, and patient states.

Costs to establish telehealth programs may be significant but should be considered in the context of potential societal and patient savings from reduced transportation, employment leave, childcare, and time spent in healthcare environments that may reduce stress and exposure to communicable diseases.

Hence, despite the grossly normal appearance of the mutant retina, these results suggest that defective signal transmission between photoreceptors and inner retinal neurons, as well as RPE dysfunction and compromised viability may be significant contributors to the etiology of RP59.

Although these species probably cannot enter bacterial cell wall, they activate the human tissue cells towards immunological mediators production. The facts presented herein may be significant for understanding the origins of the toxic effects induced by the drugs. 66 W.

G-CSF and G-CSFR expression in the primary and metastatic tumors in our cases may be significant in the etiology of tumor progression.

In atmospheric aerosols, photochemistry of DNP at the water–air interface, as well as in bulk solution, may be significant.

Transplantation of ITT generally leads to the resumption of spermatogenesis, which may be significant when considering the possible future applications of transplanting testicular tissue from pubertal patients.

This idea may be significant in formulation of theoretical frameworks in motor control.

Taken with the interactome observed for the 9 mRNA binding/splicing factors, there may be significant opportunity for overlap between these factors and other splicing factors in contributing to regulation of BMP4-dependent transcription.

Furthermore, there may be significant differences in airway microbiome in asthma patients of different ethnicities or racial groups, and while these differences may be multifactorial or related to socioeconomic status, they may be impactful in disease progression and require personalized therapeutic approaches.

This behaviour occurs because of imperfections in received symbol data may not be significant for the demodulator to corrupt data, but it may be significant to become a cause for concern.

23 Given the known microvascular damage in PAH, the role of KLKB1 and other members of plasma kallikrein kinin system may be significant cardio‐pulmonary regulators in PAH and require further investigation.

46 We consider that the interaction of the COMT risk variant with the ADHD diagnosis in the R-cingulum (cingulate cortex) may be significant from this perspective of view.

1 However, there may be significant ascertainment bias underestimating the true prevalence of MS in low- and middle-income countries (LMIC), as there is close to a 100-fold difference in the availability of magnetic resonance imaging (MRI) scanners between the Western Pacific (0.35/100,000) and Africa (0.004/100,000). 1 This makes it difficult to apply the most recent diagnostic criteria, involving imaging.

While the high amounts of amino acid diversity suggest there may be significant functional differences among allelic variants segregating within populations, indirect tests of selection could not conclusively identify a signature of historical selection.

In the latter case the different intervening tissue between the bead and the retina that is exposed to the BMP signal may be significant; when a bead is implanted in the lens the intervening tissue is the lens, whereas from a bead located in the mesenchyme, the BMP signal has to pass through the presumptive RPE.

Although the difference of 10 min in recovery between the groups may not sound as too much of a difference, in setups with limited resources where a formal PACU is lacking and the patients’ tracheas are generally extubated on table and patients are shifted directly to wards, this time may be significant enough in a working day to squeeze in another short-duration surgery.

This may be significant enough to cause reflux oesophagitis or, in severe cases, aspiration pneumonia. 25 Psychological distress owing to the visibility of NGTs should not be underestimated, with NGTs serving as a tangible reminder of illness. 19 , 26 Guidelines suggest that NGTs are suitable for patients anticipated to require EN for short periods of 4–6 weeks. 27 , 28 Dislodgement requiring reinsertion is common.

The cooperative motions of the Site3 GlcNAc and the Phe410 side chain may be significant from the mechanistic viewpoint.