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“may be significant”

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In the literature

This may be significant in diabetes pathogenesis, as TSH level has been negatively associated with various measures of insulin sensitivity.
Physiology of Sleep.
Diabetes Spectr · 2016 · PMC4755451
The present study aimed to understand the pathogenesis of CSI by NF-PitNETs from the perspective of cholesterol metabolism, and discover hub cholesterol metabolism-related genes, which may be significant markers for the diagnosis of invasiveness and provide potential therapeutic modalities for NF-PitNETs.