Barely Significant
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“may be significant”

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In the literature

point to specific intervention components which may be significant for successful interventions: high-quality training and continuous support of intervention facilitators, involving the participating older people in the planning, implementation and evaluation of the intervention, and utilising existing community resources [ 21 ].
In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis.
Crosstalk between zinc and free fatty acids in plasma.
Biochim Biophys Acta Mol Cell Biol Lipids · 2019 · PMC6372834
As far as population variability is concerned, the inter-individual differences in human populations with respect to mitochondrial genetic variation, baseline metabolism, inflammatory burden, and compensatory capacity may be significant factors in determining if a particular mitochondrial-targeted therapy restores the adaptive balance or exacerbates dysfunction in an individual patient.
First, there may be significant temporal displacement between feather growth (and associated deposition of pollutant in the feather) and collection of internal tissues, during which time post feather-growth changes in diet and/or fat mobilization may alter internal tissue contaminant concentrations (García-Fernández et al. 2013a ; Eulaers et al. 2014b ).
Blood loss Craniofacial surgeries involve major soft tissue and bony reconstructions that can result in major blood loss which may be significant enough in smaller children so as to qualify for almost whole body transfusion.
Unfavourable results in craniofacial surgery.
Indian J Plast Surg · 2013 · PMC3901901
This technique has some disadvantages: there may be significant iatrogenic paraspinal injury caused by large incisions, dissections and muscle retraction that can lead to fatty degeneration of them and scarring; it may be difficult to correct coronal balance and to restore lumbar lordosis; in addition there could may be an injury of nerve roots due to retraction, causing fibrosis and chronic radiculopathy ( 25 ).