Barely Significant
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“may be significant”

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In the literature

Furthermore, lung function at rest and during exertion are reasonably improved.[ 2 29 30 31 ] Disadvantages Efficacy of the procedure sharply declines with increasing age (due to decrease in pliability of the chest wall).[ 14 ] There may be significant postoperative pain lasting months (limiting strenuous physical activity).[ 37 ] Some relapse of the deformity after bar removal may also appear.[ 36 ] Another drawback is the inability to satisfactorily treat an asymmetrical pectus excavatum or pectus carinatum.[ 14 ] Complications Over 90% of cases yield good results resulting in immense patient and family satisfaction.[ 36 37 38 ] Overall incidence rate of complications was higher (almost 20%)[ 14 ] in initial cases but came down to <10% in later studies.
The regulation of da expression by NΔCterm may be significant for embryogenesis. da genetically interacts with Notch ( Brand and Campos-Ortega 1988 , Brand and Campos-Ortega 1990 ), it is required for development of the nervous system from neuroblasts but not for lateral inhibition ( Caudy et al. 1988a , Caudy et al. 1988b ; Vaessin et al. 1994 ), and the Daughterless protein promotes DNA-binding activities of the proneural Achaete-Scute Complex proteins ( Dambly-Chaudiere et al. 1988 ; Murre et al. 1989 ; Cabrera and Alonso 1991 ; van Doren et al. 1991 ).
That these are retinal studies may be significant, because the retina has the greatest concentration of mitochondria in the body and shows a marked decline of mitochondria with age [ 28 ], leaving significant room for therapeutic action to any agent that has the ability to improve mitochondrial function.