“likely to be significant”

As the prevalence of moderate or severe AS is approximately 4%, the number of false positives is likely to be significant despite the high specificity of the technology, and the SCG analysis needs to be integrated into a comprehensive clinical evaluation.

8 With historical studies demonstrating a reduction in secondary stroke risk from 12% to 4% per year (hazard ratio, 0.34; 95% CI, 0.36–0.79) in patients randomly assigned to receive anticoagulation or placebo following stroke, the risks of delaying anticoagulation in this cohort of patients are likely to be significant. 50 This observation was recently supported in the EAST‐AFNET 4 (Early Rhythm Control Therapy in Patients with Atrial Fibrillation) study, where lower stroke rates were documented in patients receiving early rhythm control compared with usual care (treatment effect hazard ratio, 0.65; 95% CI, 0.44–0.97). 51 Furthermore, a proportion of patients may never develop AF but remain at high risk of embolic stroke attributable to underlying atrial disease in keeping with an atrial cardiomyopathy.

Although the offset that we detected in the cochlear basal turn was only a few nanometres, it is likely to be significant for several reasons.

Lastly, a particular concern was the high level of heterogeneity observed for both placebo controlled and comparator controlled studies and our inability to identify variables likely to be significant contributors to this heterogeneity.

Several firms, several days If investors have anticipated the event, the run-up abnormal returns are likely to be significant, but this may also be the case due to insider trading before an announcement.

The study noted that although there is no mention of adaptation to sea level rise and migration, either internal or trans-boundary, both are likely to be significant issues for certain regions of Africa as the climate changes.

Moreover, one review of DiD studies found that pre-trend testing is rarely used in studies with large numbers of observations as even small differences in pre-implementation trends are likely to be significant. 18 The authors of this review highlight how pre-trend testing is more often used in studies with small numbers of observations when the test could fail to reject parallel trends because it is underpowered rather than due to parallel trends. 18 For the second assumption, we constructed a control group of low value procedures that should not have been impacted by disinvestment in the low value procedures targeted by the EBI programme during our period of analysis.

Theoretically, vitamin C may cause too much iron absorption but this is likely to be significant only in persons who have high iron stores or in patients with iron overload, such as hereditary hemochromatosis, where an increasing iron toxicity risk may exist [ 29 ].

As discussed above, the influence of household type on loneliness and social isolation among older adults is likely to be significant.

Thus, it appears that there is likely to be significant overlap in monocyte uptake mechanisms between MVs and exogenously administered immunomodulatory microparticles (e.g. i.v.-injected mesenchymal stem cell-derived MVs or synthetic microparticles), which would be an important consideration for such therapeutic interventions.

Expression of ~5.7% of miRNAs was altered in the maternal HF fed offspring A cut-off threshold of 1.5-fold change [ 48 ] in miRNAs was used to determine whether altered miRNAs levels were likely to be significant.

In relation to the other outcomes, there is likely to be significant heterogeneity between studies in terms of participants’ diagnoses, settings, and outcome measures, so a ‘structured synthesis’ approach will be used.

Secondly, as previously discussed, the lung volume reduction effect is likely to be significant in these patients with severe COPD.

The magnitude of home deliveries is likely to be significant.

− 0.0057 ± 0.0030 at 347.29° for protanomalous; − 0.0016 ± 0.00067 at 306.01° for deuteranomalous) are then also likely to be significant.

A feature that consistently appeared across many material classes was more widespread (and thus more likely to be significant) than a feature that appeared in only one or two material classes.

Transport distances should be limited to below 200 km (125 miles) or shorter if there is likely to be significant travel at <60 km/h (37 mile/h).

A potential explanation for why the number of edges and the strength of edges may explain similar variance in normalized synergy is that stronger edges are more likely to be significant.

However, the burden on educators to safely implement this in rooms with infants and toddlers is likely to be significant, and perhaps why progressive meals were rarely used at lunchtime in the current study, and only with older children who are largely independent with self-feeding.

The long-term health and economic consequences are likely to be significant considering the existing poor health systems, lack of qualified health professionals, and the increase rates of obesity in this region.

Because these studies were focused explicitly on genetic rather than demographic processes, it is difficult to know whether these effects are likely to be significant relative to other population-level processes in natural systems.

However, a clear limitation of this analysis is the exclusion of the costs involved in the clinical management of these patients, which are likely to be significant when cascade testing is also included in the ‘patient’ pathway.

myopericarditis, ischaemic, and arrhythmias 49 ), there is likely to be significant overlap between these groups.

For example, there are likely to be significant transcultural differences in CSBD and clinical characteristics (eg, attitudes toward PPU). 142 In addition, sexual medicine experts have knowledge and expertise regarding a range of sexual behaviors and sexual disorders, as well as an understanding of sociocultural influences, including an appreciation of the effects of minority stress. 143 They possess the medical background to understand links to a variety of medical conditions, medications, and drugs known to affect sexual functioning and behavior.

However, as the method for systemic vascular resistance assessment was applied identically across the entire study cohort, the intergroup differences demonstrated in the study are likely to be significant.