“likely to be significant”

This spatial heterogeneity is likely to be significant, due to the global diversity of agri-food systems and development trajectories (Malek and Verburg 2020 ; Marshall et al. 2021 ).

In HLA-DRB1*0401 transgenics, we confirmed that in the context of a given HLAII heterodimer, the N501Y mutation can result in ablation of this part of the T cell response, demonstrating that HLA polymorphisms are likely to be significant determinants of responder and nonresponder status with respect to vaccine escape.

Finally, the LSM threshold of 20 kPa could be useful clinically as a value above which fibrosis is likely to be significant, while if below could indicate a greater contribution from hepatic congestion.

What is more, decreased utilization of brain glucose and vascular disturbances are likely to be significant factors in influencing the course of AD [ 13 ].

Though genetic analysis demonstrated that each trial was similarly sampled, there is still likely to be significant intra‐accession variation.

Conclusions Sociotechnical challenges associated with the effective integration of robotic applications in health care settings are likely to be significant, particularly for patient-facing functions.

In this light, our work on addressing the specificity of biosensor binding using NMR structural analysis is likely to be significant.

Overall metabolites with consistent profiles between individuals were more likely to be significant at the group-level (Fig. 4D ), and metabolites that had either a wide range in acrophases for rhythmic metabolites, or opposing slope directions for linear metabolites, were not significant at the group-level, despite being significant in approximately half of the participants (Fig. 4E ).

pombe but are likely to be significant, possibly resembling the situation of mammalian mitochondria; however, the Sp Pol4 marked preference for undamaged nucleotides suggests that in a physiological context, the oxidized nucleotides will be probably outcompeted by dGTP/GTP and dTTP/UTP.

Although both series have been successfully used to block FFA1 responses in rodent insulinoma cell lines ( 25 , 51 ), we find that, at least in a Ca 2+ mobilization assay, although GW1100 has similar activity at human and rodent orthologs, the Pfizer compounds are significantly human selective ( Figure 1 ), suggesting that there are likely to be significant species ortholog issues to be considered when using these FFA1 antagonists in nonhuman systems.

Hot flashes, characterized by a sudden rise in body temperature and vasodilatation, resulting in a flushing sensation, are likely to be significant contributors to nocturnal awakenings.

Therefore, we reasonably anticipate that NFL and GFAP are likely to be significant prognostic predictors in participants with pre-existing AD pathology, primarily because these participants have a high probability of marked fluctuations in neurodegeneration, neuroinflammation, and cognitive function.

The acceleration of interdisciplinary research inspired by the COVID‐19 pandemic has shown that airborne transmission is a major mode of transmission for this disease, and is likely to be significant for many respiratory infectious diseases.

All scan reports where the imaging was not reported as ‘normal’ were reviewed by a consultant neurosurgeon, (PB), to assess whether the abnormality identified was likely to be significant in the context of the referral history.

In addition, reductions in sleep reactivity and anxiety sensitivity by CBT-I are likely to be significant mediators that reduce the severity of insomnia [ 16 , 17 ].

Discrepant outcomes added or upgraded from secondary to primary at the review stage were more likely to be significant than those outcomes that had not changed.

The chi-square value was not interpreted because it is sensitive to sample size and is likely to be significant in large samples regardless of model fit ( Kline, 2011 ).

The relationship between socioeconomic factors and health outcomes are likely to be significant in determining the use of mental health and social services.

Furthermore, since SAT represents a much larger proportion of total adipose tissue mass than VAT 27 – 29 , its contribution to the systemic inflammatory burden to which skeletal muscle is exposed is likely to be significant.

While the sample sizes are small, the P-values associated with a Wilcoxon signed-rank test indicate that these differences are likely to be significant.

All selected models are likely to be significant based on the model F-values of 63.84 and 56.05.

Given that there are likely to be significant differences on how data was collected between the spatial and single-cell datasets, correcting for batch effects, a highly studied phenomenon in the literature, is a natural and valuable step to add to this process.

Consequently, the impact on the oldest-old is likely to be significant.

However, the improvement in efficiency, quality of care, public satisfaction and healthcare policy-making is likely to be significant.

Results were less likely to be significant when the outcome was a continuous variable (e.g., number of hours of missed work) compared to a dichotomized variable (yes/no).