“likely to be significant”

These values are likely to be significant underestimates of variant calling quality, considering known errors in the truth set owing to the inherent limitations of reference-based variant callers (see below).

In this process, precision in terms of timing and voltage parameters is likely to be significant and often goes beyond the ability of neuronal models which use estimations and averaging due largely to lack of precise data.

The economic and social costs of the COVID-19 outbreak are therefore likely to be significant and long-lasting in South Asia.

Patients were not classified into acute and chronic groups, so there is likely to be significant selection bias between the two groups, which will be strengthened in more detail in future studies.

For creating environmental impact assessments, risk assessments for a given activity are only required if impacts to the environment from the proposed activity are likely to be significant (LGEEPA 2000 ; CEAA 2017 ; CEQ 2007 ) (Appendix S3 ).

Our results suggest that there are likely to be significant gains from targeted registration efforts.

From these plots, the covariates that are most likely to be significant can be identified, and then tested formally in the model.

The impact of this work is likely to be significant due to the unprecedented public health challenge of PCOS in young Australian women for which we currently have no optimal treatment.

These savings are likely to be significant given the average lifetime cost of skin cancer in NSW is AUD$44,796 per melanoma case and AUD$2459 per NMSC case.

It should be noted while that our analysis calculated an average time to progression through different TNM stages, there is likely to be significant heterogeneity in the rate of progression of pancreatic cancers in individual patients.

The prevalence of bronchiectasis aetiologies varies geographically and there is currently a paucity of data from lower-middle income countries (LMICs) where the burden of vaccine-preventable respiratory diseases and tuberculosis are likely to be significant contributors ( 6 ).

34 , 41 The molecular mechanisms causing the initiation and progression of NAFLD have yet to be fully recognized and understood; however, inflammation and oxidative stress induced by reactive oxygen species are likely to be significant mechanisms that can lead to hepatic cell death and tissue injury. 80 NAFLD is usually believed to have a mutual and bidirectional nexus with metabolic syndrome and its individual components and, therefore, to be a noncommunicable disease.

Species in Cycas and to a lesser extent Podisma pedestris , occur in relatively isolated populations today (both perhaps from much larger ancestral populations) where the effects of genetic drift are likely to be significant.

This small but reproducible signal is likely to be significant, as it was abolished in an mre11 mutant, in which ssDNA forms more slowly ( Lee et al., 1998 ) ( Figure S4 ).

These pathways are likely to be significant as the response of RNA metabolism to stress plays an important role in the pathophysiology of neurodegenerative diseases.

Negative scores were considered likely to be significant contributors to parasite fitness.

36 , 37 , 49 , 50 , 51 , 52 Downstream repercussions of changes in tail‐anchored protein insertion in neurons are likely to be significant: mutations in the GET protein WRB, for example, result in neuronal phenotypes. 53 , 54 Thus, future validation studies investigating the consequences of changes in CAMLG expression, and of V78I, on neuronal lysosomal function and handling of “proteinopathies” such as misfolded aSyn in model systems such as neuronal culture or transgenic animals, are easy to envision and would be a valuable addition to the work presented here.

Since there is a direct bond between the paramagnetic Ln and 31 P nuclei, CS, PCS, and PSO contributions to the paramagnetic shift are all likely to be significant; conversely, for the shifts of 1 H nuclei in paramagnetic 1-Ln , the PCS term will dominate.

There is also likely to be significant variation between patients, including variation in their disease course or treatment.

However, an eGFR of 90 ml/min/1.73 m 2 was associated with an error range of 62-100 ml/min/1.73 m 2 (−31-11%), which is likely to be significant.

It is worth considering that this isolated case has many limitations when conferring effects more widely, with inter-individual variability likely to be significant from a drug metabolism, drug-tolerance and individual dose adjustment perspectives.

Job crafting focuses on employees’ motivations and actions and tells us little about how job crafting affects (and is affected by) other members and the group as a whole, though these contextual effects are likely to be significant ( Berg, Wrzesniewski, and Dutton, 2010 ).

Although the costs associated with unrecognised and unmet needs of autistic individuals is not known, there are likely to be significant financial implications which should be explored in the future.

Similarly, the relation between connecting filament (kettin and projectin) isoforms and thick filament composition in insect flight muscle is likely to be significant given the large contribution of the connecting filaments to active properties in this muscle type [ 69 , 103 ]. 2.4.

The sample size of the flat neighbourhood was larger, which implies that the associations from this sample were more likely to be significant.