“likely to be significant”

While statistically the detected changes in phosphorylation of peptides with fold change values 1.32–1.55 are less likely to be significant, this set of peptides includes known SRC targets such as p120 and p130Cas, supporting the hypothesis that such peptides may in fact be regulated by CSF-1R-induced SRC activation.

Nevertheless, when a sequential Bonferroni [ 42 ] adjustment was used to avoid the so-called “multiple comparison problem” (where with a significance threshold p -value of 0.05, 5% of tests are likely to be significant by chance), only two loci (HPRTB and DXS10148) were found to be out of HWE ( Table S2 ).

26 Variation between clinicians in coding practices is likely to be significant both within and between practices, but this information was not accessible for the study, and its analysis would introduce multiple hierarchical dependencies outside the scope of this work.

Postoperative infections, documented in up to 25% of patients, are also likely to be significant, aligning with recent evidence from Bessa et al.

The activation of Fox0 is considered likely to be significant in the metabolic changes that underlie diabetic cardiomyopathy, but further studies to develop this prediction are required [ 19 ]. 3.

As expected, functional variants are enriched for indels (5.8% more likely to be significant compared with SNPs), making them especially relevant to include.

In this regard, as pointed out by [ 9 ], while p-values are highly influenced by sample size and more likely to be significant when the sample size is large and less likely if the sample is small, effect size estimates, in contrast, are not sensitive to it.

Within a QTL region, the effects of variants with the highest imputation accuracy, which are not necessarily the same across breeds, were probably estimated more accurately and were thus more likely to be significant.

From a statistical point of view, the same difference between the calculated and determined values of dietary AA digestibility was more likely to be significant in the cecectomy method than the slaughter method because of less SE in the cecectomy method.

The impact of the new rules on social care are not yet evident, however are likely to be significant in the broader context of high vacancies and turnover in the sector and pressures created by the COVID-19 pandemic (Dromey & Hochlaf, 2018 ; MAC 2018 ; Morris, 2020 ; Skills for Care, 2020 ).

There is likely to be significant parental anxiety associated with the event and it is important to rule out important underlying conditions, as well as to provide important information to the parents.

Given that the random and dynamic expression of RME genes potentially generates a mosaic expression signature, the ratio between cells expressing mutant alleles versus wild-type alleles in various tissues or organs, together with the timing of these expression patterns at specific developmental stages, are likely to be significant factors in autosomal dominant diseases with regards to their penetrance and expressivity ( Figure 2 ).

Therefore, we believe our results are more globally applicable to LCIS and that alterations identified in other pathways not specifically validated in this study are nonetheless very likely to be significant.

The normal P-P Plot indicated that the values of the residuals were normally distributed and there were no influential cases biasing the model where the Cook’s distance values were all under 1 suggesting that no individual cases were likely to be significant outliers.

Attitude of parents toward vaccination against COVID-19 for their own children was more likely to be significant and impacted by gender, nationality, job status, level of income and if their child had previously received influenza vaccine.

1) Age and hypertension are known to be strong risk factors for small vessel disease, while other risk factors such as coronary artery disease, metabolic syndrome, diabetes, and renal impairment are also likely to be significant, although these findings are not consistent and require further investigation. 2 , 3 , 4) Helicobacter pylori is a gram-negative, spiral bacterium that infects the gastric mucosa and causes various gastrointestinal diseases such as chronic gastritis, peptic ulcers, and gastric cancer. 5) The seropr

Monocytes are involved in both tissue injury and repair; a disproportion of this balance in HF is likely to be significant in disease development.

The analysis of immune cells revealed that CD8+ T cells and CD4+ T cells (including CD4+ naive T-cells, Th1 cells, and CD4+ Tcms) were likely to be significant contributors, as they exhibited a strong correlation with disease activity.

Despite these limitations, this study provides novel information that complements that produced from research cohorts for which there are likely to be significant ascertainment bias and it provides a profile of routine clinical care for a rare cancer predisposition syndrome at a national level in a country with a universal healthcare system.

An average of only 57 rabies cases have been reported in animals from the whole of India annually since 2005 [ 26 ], and there is therefore likely to be significant underreporting.

The development potential of such systems is likely to be significant.

The smoking-caused burden of disease is most likely to be significant in men, as illustrated in the present study.

Specifically, we argue that the effect is more likely to be significant among individuals for whom the corresponding identities are integrated rather than segregated.

The presence of such organised trapping activities and its impact on bird populations is likely to be significant [ 5 , 15 ] and it requires different anti-trapping strategies than the rest of the trapping community.

Though this second connection may introduce some intravascular air into the patient, this step only accounted for an additional 2–3% increase in intravascular air volume, on average, during our study, suggesting it is less likely to be significant.