“likely to be significant”

28 Based upon the standard of disclosure set out in Montgomery , 29 one would think that there were four key aspects relevant to the decision in Grimstone : (i) its confirmation that the Bolam standard no longer applied in determining what information a patient should be given; (ii) its requirement to disclose material risks, those being risks that were likely to be significant to a reasonable patient, or this particular patient; (iii) its inclusion of the requirement to disclose reasonable alternative or variant treatments; and (iv) its requirement that patients be made aware of the comparative risks and benefits of the proposed treatment and reasonable alternatives or variants of it.

Integrating abiotic transformation processes Hydrolysis and photolysis The role of hydrolysis is likely to be significant to only a relatively small number of chemicals, due to its pH dependence, and is adequately addressed by current guidance.

7 8 The potentially life-changing nature of stroke and the need for ongoing coordination of care services throughout recovery are likely to be significant stressors that contribute to the aetiology of these outcomes for stroke survivors.

Abstract Background Indonesia reports the second highest dengue disease burden in the world; these data are from passive surveillance reports and are likely to be significant underestimates.

The study characteristics listed above are likely to be significant contributors to the observed between-study high heterogeneity ( Table 2 ).

We associated a given gene with a given response signature set if that gene was more likely to be significant (z > 3.09) within that set of compounds than expected by chance, based on all significant scores for all chemicals, using the hypergeometric test.

Hence, in this review, we focused on the outcomes most likely to be significant to patients with DKD, for example, UAER, ORR, Scr, 24 h UTP, and AEs.

RANTES is likely to be significant in airway inflammation, since blocking antibodies to RANTES reportedly inhibit airway inflammation in a murine model of allergic airway disease ( 8 ).

Although all the plausible residues could be plausibly antigenic, the most likely to be significant are 66 and 146, which both contact known antigenic sites on the surface of the protein.

1 The impact of strength of cough is not known but its importance is likely to be significant in the context of stress urinary incontinence, syncope and rib fractures. 2 There is a need to better understand and measure cough strength because therapies may have different effects on cough frequency and strength. 3 Cough strength can be objectively assessed by measurement of cough flow, oesoph

Although HRD is considered an early, primary event in MM, there are likely to be significant structural changes that occur between diagnosis and relapse (subclonal evolution).

Although the mechanisms involved in biological responses resulting from such environmental changes are complex, the ecological effects are likely to be significant for the estuarine benthic macrofauna and hence the consumers they support.

14 The carbon emissions of clinical trials for neurological disorders are likely to be significant because the disease burden provokes clinical trial activity, and they use a wide range of drugs, devices and outcome measures including brain imaging. 15 17 Therefore, we set out to apply the Low Carbon Clinical Trials Group’s carbon footprinting guidance to a sample of clinical trials focused on neurological disorders.

Costs of registration There are likely to be significant costs to a national registration scheme.

In fact, there are likely to be significant risks relating to hallucinations (AI‐generated content that is false or not supported by the input data), paradoxical outcomes on workflow (i.e., increase in documentation time to review AI outputs compared to business as usual), and serious ethical considerations, such as privacy and informed consent [ 12 ].

Moreover, the cost of sub-clinical infection, which is likely to be significant, is not included in the above figures ( Nieuwhof and Bishop, 2005 ).

How these different information streams are integrated to support memory is still open to conjecture but interactions between the head-direction signal and theta are likely to be significant ( Aggleton et al., 2010; Jankowski et al., 2013 ).

As in European countries, the involvement of pork-related foods in food-borne HEV infection is likely to be significant.

Both current and projected indirect costs are likely to be significant underestimates due to difficulty in obtaining accurate data and the fact that the social, psychological and emotional effects of obesity which contribute to indirect costs are hard to quantify.

These challenges are likely to be significant particularly in the context of fragmented concurrent powers in Austria and Germany.

However, WHO estimates indicate that this is likely to be significant under-reporting, with a probable 73,000 people had tuberculosis in 2020 in Afghanistan [ 5 ].

The impact of this variable is likely to be significant but has never been systematically addressed.

Those are likely to be significant confounders. 5.2.3.

The durability of the flashlamps in a Traser are likely to be significant, given the relatively low peak powers and longer individual pulse durations (0.45 msec) and the consequent wear and tend on both the lamps.

The limited reporting of adverse effects in neonatal transfusion trials, the quality of the studies identified as well as the risk of bias inherent in studies in this area are likely to be significant limitations to our review [ 9 ].