“likely to be significant”

The associations outlined in the present study were more likely to be significant in subjects without underlying CVD.

Coefficients with t values of effects above the Bonferroni line are designated as significant coefficients coefficients with t values of effects between Bonferroni line and t limit line are termed as coefficients likely to be significant; coefficients with t values of effects below the t limit line are statistically insignificant coefficients [ 20 ].

Further studies are needed to determine the clinical significance of worsening anemia; however, it is likely to be significant considering that HAA has been shown to be associated with worse health outcomes, increased hospitalization, and higher mortality to name a few.

The variants that are known eQTLs for genes, and thus have been shown to be associated with expression, as most likely to be significant are labeled Category 1; those eQTLs not associated with any other functional annotation are labeled Category 6 [12] .

Results were less likely to be significant when the outcome was a continuous variable (e.g., number of hours of missed work) compared to a dichotomized variable (yes/no).

In the neural dataset, genes with a large total isoform usage change were likely to be significant for DIU and undergo isoform switching, regardless of gene expression fold change.

There are likely to be significant baseline imbalances between the cohorts in these studies.

The contribution of FR α to pemetrexed transport is likely to be significant in cells in which FR α is highly expressed.

A difficult question for future studies is how does NOD2 function as an immune tolerance checkpoint, either in the context of Crohn’s disease or immune reactions to cancer? In the context of the findings here, how does lower NOD2 signaling increase tumor infiltration with effector CD8 T cells and the therapeutic immune response to anti-PD-1? The role of NOD2 in sensing the large commensal population of gut bacteria seems likely to be significant, since germ free mice treated with anti-PD1 mount a poor immune response to MC38 tumor cells that is restored by a defined gut bacterial mixture, with the restored response dependent upon CD8 T cells ( 64 ).

As such, there is likely to be significant variation in reporting some aspects of this testing, for example reporting fetal gender, screening for sex chromosome aneuploidies and other chromosome rearrangements.

Although NITAG development is crucial, only functional NITAGs are likely to be significant partners in national public health policy-making processes and we chose to focus on functionality as the most meaningful outcome.

In addition, for increased survival times and an improved performance status, studies at the molecular biological level, including resistance mechanisms and targeted therapy (for example, antiangiogenic biologicals or trastuzumab in patients positive for HER-2), are likely to be significant issues in the future.

Therefore, an alternative scheme to mark changes that are likely to be significant was devised: if the initial r.m.s.

Injuries to the head are also likely to be significant, though not necessarily, by indicating cerebral change such as to cause slowness of perception, rapid fatigue, exaggerated emotional state, or sensibility to changes in atmospheric pressure.

If Paths a and b are significant, it implicitly suggests that Path c is also likely to be significant, even if it is not directly measured [ 25 ].

Antiplatelet use was unavailable but likely to be significant, given high vascular disease and stroke/TIA rates, and guideline recommendations in low/intermediate-risk individuals.

7 Level of education, antenatal and postnatal family planning counseling, menstrual cycle return, breastfeeding status, and return of sexual activity are likely to be significant determinants of family planning uptake. 6 - 8 During this extended postpartum period, 95% of women in low and middle-income countries want to avoid pregnancy within the next 2 years, but 70% are not using contraception. 9 - 11 Closely spaced pregnancies are associated with higher risks of abortion, hemorrhage, anemia, and unfavorable pregnancy outcomes such preterm birth and small for gestational age newborns.

There were marked associations for increased fat mass for the grandchildren if a maternal or paternal grandparent had smoked regularly in adolescence; the associations at age 17 tended to be more likely to be significant at the P values we have used than those at age 24.

Although the number of large herds in Ethiopia are few (even in the central part of the country) their impact on bTB transmission is likely to be significant as many of them are highly infected and they are primary suppliers of heifers to smallholder farms as well as of milk to consumers and could therefore be most potential sources of infection.

The impact of the pandemic itself and the measures taken to contain the spread of COVID-19 (e.g., quarantine) and their subsequent social and economic consequences on mental health and well-being is likely to be significant (Galea et al., 2020 ; Rajkumar, 2020 ).

With recent advancements in machine learning approaches to systematically quantitate localization and protein abundance levels [ 62 ], there is likely to be significant pay-off in using HCS to study KAT and KDAC functions.

While part of the reduction in activity may be accounted for by reduced prevalence of infective conditions and greater parental empowerment and confidence in managing self-limiting illness, 4 40 there is likely to be significant ongoing unmet need for specialist paediatric care.

The timing of the switch from ‘N+/C–/S+’ to ‘N–/C+/S–’, at ∼4.0 kyr BP, is also likely to be significant (Fig. 5 ).

These authors showed that Ogre elements are the main drivers of genome size variation in this tribe, while recognizing that “contrasting population sizes and different ecological and mating strategies” are likely to be significant forces shaping the retroelement composition of plant genomes.

Lack of computer literacy and online access are likely to be significant factors affecting patient engagement with ePROs in the real world, and lower education level and non-working status are also possible barriers [ 15 ].