“highly significant”

Strikingly, ontology analysis resulted in a highly significant enrichment for genes involved in the regulation of insulin transport (hypergeometric test p-value < 10e-33).

The correlation is highly significant (χ 2 = 150.17 for df = 3, giving P = 1.20 × 10 −32 ).

We found a highly significant overlap between them (265 pairs, p = 1.4E−32, Fisher exact test, Fig. 6c ).

This is a 200-kb region centering at a highly significant risk SNP rs12579077 ( P = 3.4 × 10 −32 ) 2 kb upstream of IGF1.

When excluding the same proportion of transcripts as above (57.5%), but considering this time the X chromosome and autosomes separately, the difference of median expression levels between X-linked and autosomal transcripts became highly significant in both sexes (6.82 vs 7.91, P <10 −31 in males; 6.85 vs 7.91, P <10 −30 in females).

Importantly, a mixed-effect model demonstrated a strong and highly significant interaction between groups and time for both accommodative eye vergence (F[1, 5,403] = 137.99, p = 1.7 × 10 −31 ) and accommodative pupil constriction (F[1, 5,403] = 126.56, p = 4.9 × 10 −29 ).

Between the two datasets of upregulated genes, 739 genes are upregulated in common, which is highly significant in a chi‐squared test for independence ( P = 1.739e‐31; Fig. 4c ).

The genes that show female-bias in all four species are highly enriched on Müller A, relative to an expected uniform chromosomal distribution, and this excess is highly significant (chi squared test, p = 2.06x10 -31 , Fig 3A and S2 Table ).

When contrasting the associations of α44C and Q between high and low risk subjects, their differences of risk and resistant associations were highly significant (exact Fisher’s p-value = 2.16*10 −31 and 1.92*10 −19 , respectively).

We also found highly significant positive genetic correlations between all phenotypic pairings (risk-taking/BIP: r g = 0.33, p = 2.35e −31 ; risky behaviours/BIP: r g = 0.24, p = 7.50 −16 ; risk-taking/SCZ: r g = 0.22, p = 7.41e −16 ; risky behaviours/SCZ: r g = 0.16, p = 2.08e −10 ), replicating previous findings [ 8 , 33 ].

A likelihood-ratio test to discern the association of the rs1426654 SNP to skin pigmentation, in addition to the influence of sex and population (caste), showed a highly significant effect of rs1426654 genotype on skin pigmentation (p = 2.4×10 −31 ) with an odds ratio of 26.2 (95% CI 12–67.5) for the A allele.

The results confirmed that the shift in the run-on ratios produced by rpb9Δ was highly significant (0.66 log 2 units in average, P = 2.54 × 10 –31 ) ( Figure 4 A).

In terms of the regulatory feature group, these 586 CpGs had over-representation of "Promoter Associated Cell type specific" elements ( p = 1.40e-04) accompanied by highly significant under-representation of "Promoter Associated" elements ( p = 2.94e-31), suggesting that the observed hyper-methylation pattern involves tissue-specific promoters.

Concordance of the direction of the effect of the largest variance component was also highly significant ( p = 5.71 × 10 −31 , Supplementary Table S3 ).

The hit SNP is in high LD with this common 2-base pair deletion (labelled as chr17:44102741:D in 1000 Genomes or as rs67759530 in dbSNP) within the probe ( r 2 = 0.91, minor allele frequency = 23%), giving rise to a highly significant association in the Illumina HT12 data set ( P -value = 8 × 10 − 31 ).

The correlation between the trial-by-trial change of phasic pupil dilation and that of absolute movement error for the group-averaged data was highly significant ( r = 0.64; P = 8.97 × 10 31 ; bootstrap 95% confidence interval: [0.43, 0.80]), suggesting that the phasic pupil dilation may reflect error size.

Vaccination also resulted in a highly significant improvement of average daily weight gain (+ 46 g/day; P = 9.55 × 10 -31 ) and carcase weight (+ 1.25 kg; P = 4.54 × 10 -05 ) as well as a shortened fattening period (-8 days; P = 2.01 × 10 -45 ). status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2008 Aug 18; Accepted 2009 Jan 7; Collection date 2009.

In areas where the absolute value of log2FC was larger than 2, highly significant genes (-log10( p -value) > 30) were primarily enriched, suggesting a high degree of consistency in differential expression patterns across various data sources.

The purple regression line shows the highly significant correlation with log(income) that has been previously identified for the Gallup data ( P < 10 −30 ).

Discussion Our GWAS across two cohorts of smallpox vaccine recipients, totaling just over 1,600 individuals, identified a highly significant (p < 1 x 10 −30 ) association signal from a region on chromosome 5 that was linked to significant inter-individual variations in IFNα response to in vitro stimulation with vaccinia virus.

africanum found that SIT 181 was always detected as a highly significant emerging strain (p<10 −30 –10 −31 ), followed by several other strains ( Table 2 ).

Suppression of PAPD4 also led to a highly significant reduction in miRNA expression, (t-test adjusted p value <1×10 −30 ), although the median relative miRNA expression value of 0.71 in siPAPD4 cells was of a smaller magnitude than observed from TUT1 suppression.

Logistic regression models predicting each treatment from diagnosis yielded highly significant associations (BH-adjusted p < 1 × 10 −30 ; Supplementary Data 5 ), indicating that diagnosis and treatment are not independently distributed.

(Of note, the EMN estimation was repeated across different p value thresholds [i.e., defined as the limit of the top 0.5% p values and top 0.3%], obtaining consistent results across all thresholds, with strong highly significant correlations with the original EMN values [all r ~ 0.84, p < 10 −30 ].) Next, taking the 7718 values as data, we used a novel contrastive trajectories inference (cTI) algorithm to aggregate the DNAm data by identifying the trajectories of individuals aligned/ordered with the severity of epigenetic alterations hypothetically associated with maternal neglect.

Correlations between video tracker drifts and their search coil counterparts were moderate (average vertical ρ = 0.58 ± 0.09; average horizontal ρ = 0.51 ± .09) but highly significant (all p -values < 10 –30 ).