“highly significant”

The Wilcoxon rank-sum test revealed highly significant differences between the distributions of between-class and within-class correlations ( p = 5.36 × 10 −4 ), confirming that samples from the same disease state exhibit systematically higher correlations than samples from different disease states.

Strains with transposon insertions in agrA , agrC , and ausA showed a highly significant reduction in PI uptake AUC (adjusted p = 5.4 × 10 −4 , Wilcoxon rank-sum test), confirming their reported roles in affecting bacterial cytotoxicity and validating our convergence analysis ( Figure 5F ; Blättner et al., 2016 ; Das et al., 2016 ; Laabei et al., 2021 ; Mairpady Shambat et al., 2016 ).

The ratio N tokens / N full population ( Table 3 ) shows a highly significant linear inverse correlation with the number of municipalities (R 2 = 0.23; p = 0.000544; see Fig 5 ).

Decreases in high-dose treated verses mock-treated mice were most pronounced and highly significant in the thalamus ( p = 0.000557 by a 2 sample t -test); no significant differences in staining were seen amongst groups in the hippocampus ( p = 0.825 for the high-dose group compared to the mock treated group and p = 0.839 for the low-dose group compared to the mock treated group, again with a 2 sample t -test).

The most significant result drawn from this study was the highly significant decrease in expression of hsa-miR-205 (adj p <0.00056 by RT-qPCR validation) in DCIS lesions with intermediate/high Oncotype DX ® DCIS scores.

Interestingly, histone concentrations, and thus cellularity, increased from the inner to the outer compartments of the disc, and showed a highly significant decrease in aged discs compared to young discs across all compartments ( Figure 1J , Wilcoxon p=5.6 × 10 −4 ; Figure 1—figure supplement 4B ).

This difference between the homozygous and control cells was highly significant (p values = 5.6 × 10 −4 and 1.7 × 10 −7 for 1401 and 1402, respectively; Wilcoxon test).

Cox regression analysis confirmed this observation: For the surrogate marker-based classification, the log-rank test was highly significant (OS: p = 0.00056, PFS: p = 0.00067), and the hazard ratios for POLE and p53abn versus NSMP groups were very low and high, respectively, for both, OS and PFS (Table 4 ).

Despite overall similar buprenorphine dosage, we found a highly significant correlation between cannabis use and serum buprenorphine level ( p = 0.000563).

Similarly, immunolabeling also revealed a highly significant increase in the GABAA‐α1 signal in GPi neurons at 18 months ( p = .00057), consistent with our SP immunolabeling data showing an abnormality in SP+ terminals in GPi at 18 months (Figure 12 ), and ISHH showed a trend in the same direction for GABAA‐α1 signal in GPi neurons ( p = .12720).

Co-expression with the β1 subunit consistently increased the mean peak currents, and this was highly significant overall (P = 0.00057, 2-Way ANOVA), with no significant differences between the current densities driven by splicing (P = 0.20 all 4 variants, 2-Way ANOVA).

Yet worth to mention, the canonical pathway CTLA-4 Signaling in Cytotoxic T Lymphocytes is also highly significant (p= 5.75E-04) through Ingenuity.

The differences were highly significant for AC005258 ( p = 0.00059), ZBTB7A ( p = 0.00181), SLC16A3 ( p = 0.00185), MBP ( p = 0.00478), SLC66A2 ( p = 0.00519), CTBP1 ( p = 0.00572), CDC42 ( p = 0.00572), ZNF516 ( p = 0.00572), SIN3A ( p = 0.0109), RUNX1 ( p = 0.0109), C15orf39 ( p = 0.0109), OAZ1 ( p = 0.01262), ETV6 ( p = 0.0166), DMD ( p = 0.02509), NFATC1 ( p = 0.03528), and AL591378 ( p = 0.03765).

Precipitation was not statistically significant ( p = 0.3166), whereas temperature remained highly significant ( p = 0.000596) with a coefficient consistent with the univariate model (0.496).

A t-test comparing RISKDIFF high revealed a highly significant difference between the two genotypes (5.0±1.3% for L/L versus −5.0±2.2% for S/L; t = 7.69, df = 5, p = 0.0006; Figure 3B ).

However, in the peritoneal cavity, a major anatomic residence of B-1 cells, neonatal SpA treatment resulted in a highly significant mean 78% reduction ( P = 0.0006) in the frequency of V H T15 transgene–expressing peritoneal B-1 cells (Mac-1 + B220 + ) (7.9 ± 1.1%, n = 7) compared with control treated mice (36.5 ± 3.2%, n = 6) ( Fig. 7 A).

The 24‐month LS meta‐analysis with five paired comparisons in 885 adolescents showed a highly significant weighted mean BMD difference of −0.02 (95% CI: −0.03 to −0.01) g/cm 2 in CHC‐exposed adolescents ( P = 0.0006).

The meta-analysis was still highly significant and showed decreased clearance in the Aqp4 KO mouse lines (−1.92 [-3.02; −0.82]; p = 0.0006) with a lower degree of heterogeneity (I 2 = 64.1%, p = 0.0103).

In Model 3 PCT + sCD14, a score of 2 is highly significant (p = 0.0006) and with increased odds (11.67 (2.82–57.08)) in the diagnosis of sepsis compared to a score of 1.

It was found that, in early AMD, after correction for age, the overall effect was statistically highly significant ( P = 0.0006).

This rate difference was both congruent with the difference in ML estimates of ω [ 2 ] and highly significant ( P = 0.0006 by Student's unpaired t -test).

Given that these patients exhibited the most pronounced alterations in PCSK9 and sLDLR levels, the correlation of the PCSK9/sLDLR ratio with the presence of ≥ 5-cm metastases was also examined, revealing a highly significant correlation ( r = 0.4527, P = 0.0006), and difference of this ratio between patients without and with ≥ 5-cm metastases (3.21 ± 1.41 vs . 1.68 ± 0.62, P = 0.0006, Fig. 2 D).

The multiple regression analyses revealed an overall highly significant correlation ( r = 0.84 and p < 0.0006).

More formally, using a mixed linear effects logistic regression model that treated dataset as a random factor (which also controlled for SNP platform because dataset was nested within each platform), the overall association between schizophrenia and Froh in the combined sample was highly significant (β = 16.1, z = 3.44, p = 0.0006 in the imputed data, and β = 17.98, z = 3.89, p = 0.0001 in the raw data).

GPT: Although depth and ramus relationship scores remained stable, a highly significant shift was observed in angulation (C3) assessment ( P = .0006), leading to a significant change in the total PDS ( P = .0007).