“highly significant”

Factors explaining seropositivity in animals In cattle, age had a highly significant effect on animal seropositivity (P-value = 0.0004), indicating that the older the animal, the more likely it is to become infected and hence be seropositive.

At the end of 12 weeks, there was a highly significant ( P = 0.0004) 20 m placebo-corrected median improvement in 6MWD.

This would be consistent with the finding in the same study of highly significant correlations between tryptophan levels in the blood and disease severity as indicated by the number of CAG motif repeats (negative correlation, p = 0.0004), and between the kynurenine:tryptophan ratio and CAG repeat length (positive correlation, p = 0.0025). 16 In neither of these two patient groups is there any available pharmacological strategy for significantly improving the long-term outcome of the brain injury or neurodegeneration, so therapeutic studies to assess responses to drug therapies as performed in osteoporosis patients (above) are not currently possible.

In the jejunum, both buprenorphine and tramadol caused a highly significant decrease in MPO activity in comparison with chemotherapy-treated control animals (53%, p = 0.0004 and 58%, p = 0.0001 respectively, Fig 2A ).

Peptide:MHC (pMHC) tetramer staining revealed a significant expansion of T cells specific for the acute, non-inflationary immunodominant epitope M45 (p = 0.0004), with smaller, but also highly significant expansion of CD8 T cells specific for inflationary epitopes m38 (p = 0.0004) and m139 (p = 0.0004) ( Fig 2E ).

Factors showed highly significant group differentiation (p < .0004) identifying 89.5% of unmedicated female CFS patients and 92.4% of healthy female controls.

The ER expression of adenomyotic foci in relation to functional and nonfunctional ovarian cysts was statistically highly significant ( p =0.0004).

1.31 ± 0.99 mg/mL, respectively; p = 0.1016), with a highly significant increase on day 3 taking into consideration the baseline status ( p = 0.0004) ( Table 2 ).

There was a highly significant correlation (p = 0.0004) between M. tuberculosis presence in the larvae and the absence of treatment ( Figure S2 ).

This difference was highly significant ( P = 0.0004); the average distributions were 64% ±17 gametocytes in the BM and 8% ±9 gametocytes in the PB (Fig. 3b ).

This led to a highly significant risk of DVT (OR = 10.1; 95%CI = 2.23-45.9; p = 0.0004) which was higher than that described in the study by Morelli et al.

The secondary comparison between PZ and TZ across all 36 patients was adequately powered (Cohen’s d = 1.34, retrospective power > 99%), consistent with the highly significant difference observed ( p = 0.0004).

Notably, intermediate-risk classification exerted a highly significant negative effect on OS (β = –0.9702; p = 0.0004), further affirming the vulnerability of this group and supporting the need for re-examination of therapeutic intensity for these patients [ 15 ].

However, we find that enrichment of functionally similar CRMs near the target gene is highly significant ( p value = 4E-4, Table S3 ).

Interestingly, however, there was a highly significant positive correlation between MDA and HMGB1 in the liver flush ( r = 0.9763, P = 0.0004) ( Figure 8C ).

The association was found to be statistically highly significant (p = 0.0004).

Complementary LSD post hoc tests revealed a highly significant difference between the JH and DMF treatments (P = 0.0004), and a very strong trend for JH vs. control (P = 0.057).

The univariate CLM indicates that predator identity of Tyto alba rather than Mustela putorius has a negative (–2.27) and highly significant ( P = 0.0004) influence on the extent of crown corrosion alone (AIC = 123.71).

FCS (supplemented normal growth medium) led to a highly significant increase in COL1 expression compared to CPRP-treated cells ( p = 0.0004), which showed a decreased expression of COL1 compared to growing cells calculated by simple ANOVA with Tukey’s multiple comparison tests.

For generosity we found highly significant correlations with total T (r = −0.25, two-tailed t test, N = 200 for this and subsequent tests, p = 0.0004), free T (r = −0.1908, p = 0.0068), and DHT (r = −0.3063, p = 0.0001); see Fig. 4A .

In comparison, only 4 of 19 (21%) CD14-KO mice developed symptoms of ECM indicating that loss of CD14 confers a highly significant protection from ECM (p<0.0004, Fisher's exact test).

In the 100–200-ms time window, masked words evoked highly significant power changes (beta suppression: p = 0.0004; high-gamma increase: p = 0.0005).

AA) further supported this finding, showing a highly significant risk elevation (OR = 2.85, P = 0.0004), and the MTHFR C allele itself exhibited the strongest allelic association observed (OR = 2.17, P = 0.0004).

Specifically, the partitioning around medoids (pam) clustering algorithm [ 29 ] with two centers predicted one cluster with 52 good outcome and 56 poor outcome patients, and another cluster with 56 good outcome and only 19 poor outcome events, which was highly significant under Fisher's exact test ( P = 0.0004; Figure 3c ).

Indeed, we found a strong and significant negative correlation between ISOA (at 86% level) and drusen eccentricity ( r = −0.72, P = 0.001) as well as highly significant positive correlation between ISOA and drusen density ( r = 0.72, P = 0.0004 across all subjects.