“highly significant”

DNAm levels captured by bisulfite Sanger sequencing allowed the development of a final APM with seven CpGs ( EDARADD CpG3, FHL2 CpG5, FHL2 CpG11, ELOVL2 CpG5, PDE4C CpG5, PDE4C CpG9, C1orf132 CpG3), revealing a very strong age correlation value (R = 0.940), highly significant ( p -value = 7.36 × 10 −79 ) and explaining 87.8% of the variation in age.

Furthermore, the overlap in hits between cell lines was highly significant ( p < 1e-78, hypergeometric test; Figure 3G ).

This result is highly significant, with P-value<10 −77 ; this p-value is calculated based on 10,000-time permutation evaluating the possibility that 66 out of 83 randomly selected regions overlap or contain with CpG island.

(We confirmed here and elsewhere that these differences were highly significant (e.g., here, the relevant comparisons are a minimum of p < 1 e −77)).

While this difference is highly significant ( p- value <10 −77 , Mann–Whitney U test), in absolute numbers the overlap is small: while a typical asthmatic subject has on average 379 perturbed genes, the average number of shared perturbed genes between two asthmatic subjects is only 24 (Fig. 2d ).

Bios Consortium database found a significant methylation quantitative trait loci (meQTL) (cg03543120, p = 1.35 × 10 –8 ), and GoDMC query found five highly significant meQTLa for rs4705342 (all p < 10 –77 ) (cg00226225, cg04317047, cg03370704, cg03543120, and cg09660867).

Results The combined loss (L RSC ) discovered highly significant prognostic subgroups ( P -value = 1.55E−77) with more accurate sample assignment (Silhouette scores: 0.59–0.7) compared to baseline models (0.18–0.3).

As additional validation supporting the role of myeloid-derived cells, and specifically monocytes, as a dominant contributor to plasma CyC levels, we found a significant positive correlation between blood monocyte counts and CyC residual in the UKB cohort ( Figure S4 B; multivariate regression), and two-sample Mendelian randomization using blood-derived CST3 eQTLs (eQTLGen 58 ) as exposure identified a highly significant positive association with CyC production (p = 6.13e−77; Figure 4 E).

Results for the theta band showed a highly significant association between the mean relevance of each brain region, and how their centrality changes in association with p-tau231 levels (rho = 0.499; p = 9.2 × 10 –77 ).

Given that our input data consisted of 979 miRNA of which 289 are related to cancer, this ratio (219 / 289) is highly significant ( p -value = 1.21-76).

Similarly, the results revealed a strong positive correlation between RA Factor and disease severity, with Spearman’s ρ = 0.902 and a highly significant P -value < 3.9 × 10 −76 ).

The overlap between the missed BUSCO genes in these two species is highly significant (more than 250 ORFs, P -value < 10 −75 , hypergeometric test), arguing for a strong sequence divergence or loss of these genes in more distant nematode lineages.

Two-tailed Mann-Whitney U test showed that the difference between them is highly significant ( P = 1.1 × 10 − 75 ).

Genome‐wide genetic correlation between T2D and CAD A cross‐trait LD score regression analysis based on a Hapmap 3 set of genome‐wide variants detected a highly significant ( p < 3.11 × 10 −75 ) genetic correlation between CAD and T2D of moderate strength ( r g = 0.40, 95% CI: 0.36–0.44). 3.2.

The Pearson correlation of individual question scores for the same participant was r = 0.19, which was highly significant with p = 7e-75 (n = 9520).

We performed reduced representation bisulfite sequencing (RRBS), 5 a technology for interrogating hundreds of thousands of methylation sites with digital precision 27 , 28 on the rat PNS and found characteristic and highly significant patterns relating gene methylation and activity (p≈1.0x10 −74 ) that differed markedly between LCP and HCP genes.

The results clearly show an overall highly significant increase in the number of such events in TA MSI clones compared to TA MSS malignant clones ( p -value < 2 × 10 −74 ).

Interestingly, nearly all of the IPR genes described above are also induced following bortezomib treatment ( Fig 6E ), an overlap that is highly significant (representation factor (rf) = 10.8; p<2.68E-74; rf is the ratio of actual overlap to expected overlap where rf>1 indicates overrepresentation and rf<1 indicates underrepresentation; see Materials and Methods ).

T2D status was found to be a highly significant predictor of weight loss efficacy ( P = 2.0 × 10 −73 ; Supplementary Table 4 ), with an average predicted reduction of 2.87 percentage points in BMI loss for people with a T2D diagnosis.

Bartlett’s test of sphericity was found highly significant for both item pools ( p < .01×10 −70 ).

1 and Supplementary File 2 ), which is statistically highly significant ( p < 10 −72 , hypergeometric distribution test).

The test was highly significant ( p = 6.77 × 10 −72 ), indicating that the data were not missing completely at random (MCAR).

As depicted in figure 2 , the overrepresentation of children of Sub-Saharan African descent across the higher quintiles of the BMD-GS was highly significant in both studies (Generation R: P = 2.7 × 10 − 71 and BMDCS, P = 2.3 × 10 − 70 ).

Lola-N binds to 1,369 genes (false discovery rate [FDR] < 0.1%) that show a highly significant overlap (p < 6 × 10 −71 ) with the 836 genes (FDR < 0.1%) bound by Prospero.

But the median z -value for the overlap of indirect and direct regulated targets is still highly significant ( z = 21.6, p < 10 –70 ), and thus, indirect regulated targets can still be used for examining the regulatory network links and functions of TFs.