“highly significant”

There was a highly significant increase in the vascular staining in both groups with DPN compared to the HV group (painful-DPN, p < 0.0001; painless-DPN, p = 0.0037), and also in the No-DPN group ( p = 0.02), compared with the HV group.

Interestingly, we also found a highly significant interaction for genotype (F [1,48] = 208.2, p < 0.0001), suggesting memory deficits in both male and female APP NLGF mice at this age.

Then, the non-parametric Kruskal-Wallis test compared ccf-mtDNA levels in the three groups, resulting in a highly significant statistical difference (p-value < 0.0001).

First, the sucrose concentration decreases in a very highly significant way ( p < 0.0001) over time (from 57.4 g/L ± 0.09 at D0 to 25.2 ± 2.85 g/L at D14), with a highly significant decrease ( p < 0.01) in sucrose content between D7 (44.2 ± 3.92 g/L) and D11 (24.9 ± 2.22 g/L).

The Wilcoxon signed-rank test yielded a highly significant result ( P < 0.0001), demonstrating a significant difference in histological scores between the jejunum and ileum, suggesting a potential systematic variation in lesion scoring across different intestinal segments.

There was a highly significant interaction with age (p < 0.0001), such that the association was only observed for younger compared with older individuals: HR 1.27 (1.15-1.39) and HR 1.00 (0.92-1.09) in individuals ≤75 years and >75 years, respectively.

Analysis results reported in Table 3 , as well as, the parameters which statistically indicated highly significant impact on the yield were linear term of pressure, CO 2 flow rate and time (p < 0.0001), followed using the quadratic term of flow rate(p < 0.0001).

The correlations between these measures are highly significant (Pearson p < 0.0001).

The effect of Run was highly significant ( F (6,2224.0) = 77.81, p < 0.0001, η 2 = 0.17): participants’ latencies decreased across successive runs of the task (973, 870, 838, 812, 801, 791, 783 ms).

However, repeating this analysis with every patient in the study population assigned a NF-κB score according to mutation status (which makes use of all study data) and relating this to affected bone numbers, the result was highly significant both when we included all patients (r = 0.277, p < 0.0001) and also when the two patients with A427D mutations were excluded (r = 0.244, p < 0.001) (data not shown). 3.4 Impact of mutations on UBA domain structure and dimerisation We next sought to understand the structural basis of the effects of the I424S and A427D mutants on SQSTM1's ubiquitin-binding function revealed in the pull-down assays ( Fig. 1 b), and in particular, given the close proximity of these mutations to the site affected by the previously characterised G425R mutant, whether common or distinct mechanisms are manifested.

The results of third pair CCA mode of network and gene variate were again highly significant (Fig. 3 C, r = 0.97, p < 0.0001), as was fourth pair CCA mode of network and serum lipid variable (Fig. 3 D, r = 0.82, p < 0.0001).

TSA treatment was characterized with a highly significant increase of LDH release, compared to controls (**** p < 0.0001), which indicated a clear increase of cell toxicity.

PCT and CRP's trend difference in nonsurvivor and survivor groups were highly significant ( p -value < 0.0001) ( Table 1 ).

This was confirmed by the Kolmogorov-Smirnov (KS) test for the slopes, which showed no significant difference between the empirical CDF of the RoPs and the estimated exGaussian distribution ( P = 0.108), but a highly significant difference with the estimated Gaussian distribution ( P < 0.0001).

Both subject groups showed highly significant improvements between the mKFT and KF ( p < 0.0001), and the difference between the two groups was minimal when the gaze was incorporated ( p > 0.99).

There was a highly significant interaction between population and temperature 2 ( F 3,2126 = 15.34, P < 0.0001) indicating that the pattern of ticks questing with temperature varied between populations.

The CT heterozygote once more demonstrated a significantly lower risk (OR = 0.36; 95% CI = 0.2–0.5; p = 0.0001) among individuals without a family history, while the TT homozygous mutant genotype demonstrated a highly significant increased risk (OR = 2.79; 95% CI = 1.7–4.3; p = 0.0001).

The one way ANOVA test revealed a highly significant difference (P-value<0.0001) in the average number of in-chorion contractions between dose groups, and the Tukey-Kramer HSD test identified all pairwise differences as significant at a familywise error rate of 0.05.

Thoracolumbar muscle hypotrophy also showed a highly significant time effect [ F (1.922, 34.60) = 22.33, p < 0.0001], although post-hoc comparisons did not identify specific time points that differed significantly from baseline in either group ( Figure 10 ).

The relative proportion of C>T/G>A changes was highly significant compared to other nucleotide changes (p < 0.0001, Kruskal–Wallis one-way analysis of variance) and formed 32% of all nucleotide changes overall, a proportion that was double what was expected due to chance.

Importantly, this relationship remained highly significant in the time-adjusted model (β = 0.000177, 95% CI: 0.000113–0.000242, F = 29.8, p < 0.0001), indicating that the structure-function correlation persists even after controlling for temporal changes during the recovery process.

Results The difference between ages of the two groups was highly significant ( P < 0.0001).

HCV-uninfected women were highly significant ( P = 0.0001).

A highly significant difference was observed between the mean of IgG1:2a ratio in resistant and susceptible mice (Mann Whitney U test, p < 0.0001, Figure 1 B).

The differences are highly significant ( P < 0.0001), except for class 2,2, probably because of its low incidence, as shown by χ 2 statistical analysis with Bonferroni correction.