“highly significant”

Around 44% of all broadly expressed genes are present in non-zero modules, amounting to a highly significant enrichment (OR = 3.58, p = 1.48e-93).

Two highly significant loci associated with idiopathic MN were discovered: the human leukocyte antigen (HLA)-DQ alpha chain 1 ( HLA-DQA1 ) locus (rs 2187668; odds ratio, 4.32; P = 8.0 × 10 −93 ) and the PLA2R1 locus (rs 4664308; odds ratio, 2.28; P = 8.6 × 10 −29 ).

A Fisher’s exact test revealed a highly significant odds ratio (OR) of 29 [95% confidence interval: 19–43] ( P = 8.5 × 10 −93 ), indicating that the odds of identifying the true causal genes from candidates highlighted by ProGeM are greatly improved when picking from the pool of concurrent candidate genes.

Approximately 1,000 of the inducible genes had an iDHS within 150 kb of the TSS, and nearly 500 of these elements were located within just 25 kb which was highly significant ( P = 10 −92 ) (Fig 4 E), further signifying a role for the iDHSs as inducible enhancers of these genes.

One-way ANOVA revealed highly significant differences in abundance, with 10 metabolites showing strong accumulation patterns (F-values 1.38 × 1031−7.84 × 1032; p < 1.03 × 10−92, FDR-corrected).

Association analysis The SNP AC000158: g.1390292G>A , within intron 3 showed a highly significant association with the polled genotype (χ 2 =423, -log 10 P=91.85) ( Table 1 Figure 1) and perfect co-segregation in all 443 Holsteins.

ActiveDriver identifies N-terminal mutations in five cancer types as highly significant ( n = 73, FDR p = 2.5e − 92 from ActiveDriver; Fig. 2b ), confirming constitutive activation of CTNNB1 via disrupted phosphorylation as a prevalent driving mechanism of cancer.

Importantly, 64 of the 126 genes were also repressed when Miz1 and Arf were coexpressed, identifying a highly significant overlap in target genes (P = 2.5 × 10 −92 ) and defining a core program of genes that are jointly repressed by Myc and Miz1 in the presence of Arf ( Fig. 6 b ).

We also showed confirmed association with AGA at AR gene by highly significant signal spanning the gene region (OR = 2.20, 95% CI = 2.04–2.37, p = 2.40×10 −91 for risk allele T of top SNP rs2497938).

On the other hand, there were 180 genes differentially regulated by both dfoxo and Xbp1 s overexpression in the fat body ( Figure 4 C) and this overlap was highly significant ( p < 10 −90 ).

Homologous motif prediction using the MEME Suite (v5.5.9) identified four highly significant conserved motifs ( p < 1 × 10 −90 ) in human WEE2 and its family kinases.

6 E ), a highly significant overlap ( P = 1.03 × 10 −90 ).

These effects were also highly significant if APOE was not included in the NN calculation of CV [CV vs. age, F (2,4752) = 422, β = −22.4, p = 5.3e-90; CV vs.

The most top and highly significant miRNA involved in this pathway was hsa-miR-34a-5p ( p = 1.275767 e − 88) with 28 target genes, including MET oncogene and three angiogenesis-related genes ( VEGFA , TGFB1 , TGFB3 ).

For the chloroplast genome, the average sequencing depth (the average number of reads representing a given nucleotide; also referred to as read depth or average cover) of silica gel dried material was 1.7 times higher than that of herbarium material, and this difference was highly significant (Mann-Whitney p = 1.8 × 10 −88 ).

These overlaps are very unlikely to occur by random chance, as even the protein pair with least common probesets has a highly significant P -value ( MCM5 and MCM6 , 47 common probesets, P < 10 -87 ).

The association of CDS Htz1 peaks with AS transcripts, although lower than the association of 3' Htz1 peaks with AS transcripts (Figure 3 D), is highly significant ( p = 1.6 x 10-87; Fisher’s exact test).

Comparing synchronized neurons with a fixed I-E delay of 5 ms, we observed a highly significant correlation (r = 0.99, P<3.1x10 -87 , Spearman Correlation, Fig. 4b ) between the excitatory input strength and the Rayleigh statistic, the criterion we used to measure the statistical significance of stimulus-synchronization.

First, we considered the intersection between differentially expressed genes and genes that are neighbours of misregulated TEs at the 2-cell stage, and discovered a highly significant overlap of 12% between the two populations (p=3.19 × 10 −87 ) ( Figure 4A ).

The three participant-specific tests revealed highly significant deviations from the uniform distribution (PA: χ2(7, N = 189) = 421.50, p = 10 -86 ; PB: χ2(7, N = 94) = 107.36, p = 10 -19 ; PC: χ2(7, N = 126) = 512.73, p = 10 -105 ).

A Mann–Whitney U test confirmed the difference was highly significant ( U = 130,876, p < 1e-86, Cohen’s d = 2.05), indicating a large effect size.

This demonstrated that BAF and p63-dependent target genes (fold change > 3 with depletion, FDR < 0.01) displayed highly significant overlap ( p = 2.1 × 10 −86 ), with 236 genes controlled jointly by both BAF and p63 (Fig. 2h ; Additional file 1 : Figure S2f, g; Additional file 2 : Table S2).

LD score regression analysis revealed a genetic correlation coefficient of rg = 0.23 (95% confidence interval [CI]: 0.203 to 0.249; se = 1.15 × 10 − 02 ), which was highly significant ( P = 2.65 × 10 − 85 ).

This was found to be highly significant (p<10 -84 , hypergeometric distribution).

For viscosity–transparency relationships, ANOVA demonstrated a highly significant association (F = 244.94, p < 1 × 10 −84 , R 2 = 0.98), where viscosity nearly fully explained transparency differences—likely linked to enhanced molecular alignment or suppressed phase separation in high-viscosity systems—with a negligible C.V.