“highly significant”

In particular, a highly significant ORR was seen in patients who developed skin disorders ( P = 0.0001), vitiligo ( P = 0.0004) and thyroid dysfunctions ( P = 0.0127) ( Supplementary Table S4 ).

The interaction between the population origin and the applied treatment showed a highly significant effect (F = 59.88, p ≤ 0.0001), suggesting that the response to damage is significantly modulated by the genetic origin of the plants ( Table S4 ).

However, a highly significant difference ( P = 0.0001) between syngeneic and allogeneic BMDCs was seen in the tumor rejection data (Fig. 2 a, c).

The M group demonstrated the smallest reduction (p< 0.05), whereas differences in the other groups were highly significant (p< 0.0001) ( Figure 8B ).

All potential covariates were non-significant and the final model contained only the highly significant effect of experiment type (F 6,113.1 = 11.46, P < 0.0001; Figure 1 ).

Results obtained on protein structures showed highly significant correlations with results obtained from literature (p < 0.0001, n = 210, four different subsets).

All models were highly significant ( p < 0.0001).

Analysis of variance (ANOVA) indicated that the selected factorial model was highly significant ( p < 0.0001).

A statistically highly significant enrichment ( p < 0.0001) of very stable interactions when using an approximate energy model [ 19 ] to match native miR sequences with the near-splice site miR:RNA and miR:DNA interactions was observed, showing much stronger and more significant enrichments for miR:DNA interactions (Figure 6 ).

The likelihood ratio test confirmed that this threshold effect was highly significant ( p < 0.0001), supporting its reliability.

Highly significant association was found between naive CD4 T cells and CD4+ RTE (all p-values <0.0001).

While this difference was highly significant in left and right-styled flowers ( p < 0.0001), the margin of success was notably reduced in straight-styled flowers ( p = 0.0139).

The model was highly significant ( p < .0001) with two predictors.

Except wattle width ( p < 0.05), the remaining seven of these eight discriminant traits showed highly significant phenotypic variation ( p < 0.0001 to p < 0.01) between female sample chicken populations.

The four distance interims also demonstrated a highly significant difference ( p < 0.0001) when compared to one another.

Statistical analysis demonstrated a highly significant difference between the two groups (p = 0.0001).

There was a highly significant decrease in the mean value in the Aspartame Group ( p <0.0001) as compared with the Control Group, and there was a nonsignificant decrease ( p > 0.05) in the Recovery Group as compared with the Control Group. 4.

The association of the modified PHQ with fatigue was also highly significant (3 months: ß = 0.59, p < 0.0001; 12 months: ß = 0.72, p < 0.0001).

A highly significant heart rate elevation following direct laryngoscopy and endotracheal intubation was recorded in all three groups (P <0.0001), but heart rate rise duration was longest in the placebo group and of shortest duration in the clonidine group (Mean HR at 15 minutes: 80.80±15.41 in the placebo vs 65.53±12.43 in clonidine group).

HCV-uninfected women were highly significant ( P = 0.0001).

The rise in seroprevalence between 2023 and 2025 was highly significant across sexes, regions, and provinces (p < 0·0001; Table 2 ).

Results A highly significant difference ( p < 0.0001) was observed, indicating that miR-21 expression was higher in CML patients compared to the controls. miR-302 levels were lower in CML patients.

The results showed a highly significant relationship ( P < 0.0001) with C max on Day 1 with an odds ratio of 1.510 (95% CI: 1.279–1.802).

Fisher exact test demonstrated a highly significant enrichment ( P < 0.0001, odds ratio: 716.8, 95% confidence interval: 179.0–2871).

The chi-square test revealed a highly significant association between receiving health education and overall satisfaction (χ2 = 148.84, p < 0.0001).