To ensure that the relationship between mean transcript abundance and transcript CV was not driving this correlation we repeated the analysis as a partial correlation while controlling for mean transcript abundance, this still showed a highly significant negative relationship between the heritability of transcript abundance and the transcript CV (P<0.0001, R2 = 0.42).
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This change was highly significant, as indicated by one-way ANOVA analysis (p<0.0001).
The difference in the slopes between the Braf wild type and mutant mucosal samples was highly significant ( P <0.0001), reflecting the temporal accumulation of DNA methylation events following induction of the Braf mutation.
For a-wave amplitude, a two-way repeated-measures ANOVA with treatment and intensity as factors found that both were highly significant ( p < 0.0001 for both), and Bonferroni post hoc tests indicated significant pairwise differences in the three highest intensities tested (−1 to 1 log cd s/m 2 ).
If we had used model 5 rather than model 1, 19.3% of those who develop CVD would be appropriately assessed for their cardiovascular risk while only 11.4% of those who do not develop CVD would be falsely assessed for their cardiovascular risk, the difference of which is highly significant (P<0.0001).
Spatial frequency, optical scattering and testing location were shown to be highly significant factors in the model with all p < 0.0001 on their own and in interactions between them.
Significant factors for the prediction of SVR For the prediction of SVR, factor X 21 (EVR) was highly significant and had a high χ 2 value (p<0.0001; table 3 ).
1 , the 6-OHDA lesioning caused a highly significant and near-complete reduction of TH ( t = 16.36 and df = 42; p < 0.0001) and DAT ( t = 24.63 and df = 22; p < 0.0001) at the level of striatum.
At 6 hpf, there was a significant difference between the control and erythritol-treated groups, and the different concentrations of erythritol-treated groups showed a decrease in similarity, with a highly significant decrease in similarity in the 5 mg/mL erythritol-treated group (H = 22.206, p < 0.0001, Fig. 2C ).
However, the mixture of 10 n m CM4620 and 1 m m galactose provided highly significant protection against BA-elicited necrotic cell death ( P < .0001) as compared to cell death levels in the presence of 10 n m CM4620 alone ( Figure 3A ).
The source of variations, agents, bacterial strain, and their interaction were highly significant P < 0.0001 ( Table S2 ).
The effects of salinity and Zn concentration on final biomass were highly significant after 90 d of treatment (two-way ANOVA, Zn×salinity: P <0.0001 for both tiller and root dry biomass).
The difference between the two lots is highly significant according to a log-rank test ( P = .0001).
As shown in Table 3 , the model was highly significant (P < 0.0001)and statistically significant.
Two-way ANOVA revealed a highly significant effect of the genotype and the distance from the soma on the number of intersections ( p < 0.0001, F (1,4023) = 37.46 and p < 0.0001, F (26,4023) = 163.7, respectively), as well as a highly significant interaction between those two factors ( p < 0.0001, F (26,4023) = 2.488).
The correlations of divergence patterns between all three species are highly significant: S. intermedius — S. droebachiensis (rho = 0.719; P < 0.0001), S. intermedius — S. pallidus (rho = 0.657; P < 0.0001), and S. droebachiensis — S. pallidus (rho = 0.748; P < 0.0001).
The correlation between this ratio and powdery mildew infection in 2001 was negative and highly significant: B1 site r = -0.509, p <0.0001 ( S3 Fig ) and P8 site r = -0.397, p = 0.0009.
With the exclusion of the initial positive report, which tends to suggest a stronger genetic effect (winner's curse) than those in subsequent studies [ 9 - 11 , 16 ], the cumulative OR decreased slightly but remained highly significant ( P <10 -4 ) with no significant heterogeneity ( P heterogeneity = 0.47, I 2 = 0%) (see Figure 3 caption).
This enrichment was highly significant (Fisher's exact test, P < 0.0001).
Our analysis revealed that the group predictor remains highly significant (p < 0.0001) even after accounting for steroid use, highlighting that sarcoidosis exerts a direct and independent effect on autonomic function.
This regression model was also highly significant and explained 42% of the variance in placebo variability (adjusted R 2 = .426; F 5/91 = 15.22; p < 0.0001).
71 Analysis of the HPS also assessed simvastatin efficacy in subjects with and without diabetes and showed an effect consistent with the full cohort; 72 that is, simvastatin produced highly significant reductions (22%; P < 0.0001) in the first event rate for major coronary events, strokes, and revascularizations in subjects with type 2 diabetes.
A similarly designed study using everolimus (initiated at 4.5 months post-transplant) in 300 patients also showed a highly significant increase in eGFR at 1 year after transplant (eGFR 71.8 versus 61.9 ml/min/1.73m 2 , P <0.0001) [ 13 ].
The number of scales did not show significant differences among the four southern phenotypes (diagonal, vertical and longitudinal bars, and stellate spot; GLM: all p>0.4), whereas the difference was highly significant between these four phenotypes and the round spot skin pattern (GLM: t = 11.9, p<0.0001).
This is a highly significant difference compared to metagenomes from individuals from other countries from which bacteroidetocin B was detected in 1.9–6% of metagenomes ( P < 0.0001).