“highly significant”

For testing the association using the proposed methods, we selected replicate 50 of the Danacaa population, because in this replicate marker D03S0127 showed highly significant linkage to the disease locus with a LOD score greater than 6 ( p < 0.0001).

In lung adenocarcinoma, many genes such as MKI67 , ANLN, NDC80 , and EXO1 showed highly significant correlations ( P < .0001 or better) with up to 15 other PAM50 genes, suggesting that these genes are concordantly expressed (data not shown).

There was no significant difference between littermate controls and Jna/+ mutants when BrdU was injected at E12.5 (F[9,189] < 1; P > 0.05), however there was a highly significant difference when injected at E14.5 (F[9,198] = 4.75; P < 0.0001), and at E16.5 (F[9,270] = 13.3; P < 0.0001).

Statistical analysis revealed a highly significant difference between the control group and the dropped group ( p < 0.0001), indicating the substantial contamination risk when grafts were exposed to the operating room floor.

When the mammary tumor survival data of all homozygous MMTV-BRCA1 and MMTV-BRCA1sv transgenic lines were compared against nontransgenic controls, a highly significant effect on mortality was noted (Fig. 7 A, P<0.0001 for both lines versus nontransgenic controls).

For stem diameter, the Treatment effect was not significant across corrections (Greenhouse–Geisser: MS = 6.23, F = 1.27, p = 0.332), but the effect of Time was highly significant (MS = 83.02, F = 123.96, p < 0.0001), showing consistent increases in stem diameter across weeks.

We found a highly significant PD induced nigral FA reduction with an estimated weighted pooled disease effect size of − 0.90 (p < 0.0001, Forrest plot see Fig. 2 , values of individual studies see the supplements, Inline Supplementary Table S2 ).

In all cases we found that this enrichment is highly significant at p < 10 -4 .

The 6-OHDA lesioning ( n = 8) caused a near-complete and highly significant (96.8 ± 1.8%, Two-Sample t -test, p < 0.0001) abolishment of DAT at the level of the CPu ipsilateral to the lesion in experimental cohort 1.

Results: All 20 observers could distinguish between round and anatomical shape in all 14 cases (100%), which was highly significant ( P < 0.0001) for each observer.

As shown in Figure 8 and Table 1 , the (N2) wild type worms showed a highly significant longevity extension when treated with 100 μM and 50 μM CA (LogRank p<0.0001), as compared to controls.

When the MGEs are included (Figure 5a ), all pairwise comparisons between the four different sub-groups (fourth, Asian, Turkish and South American) show highly significant differences ( P < 0.0001; red arrows) except for the fourth sub-group versus South American ( P < 0.05; brown arrow).

Treatment with AC102 showed a concentration-dependent decrease of morphological cell damage, with a significant decrease at 30 μM (66.5 ± 9.51%, p = 0.028) and highly significant decrease at 100 μM (35.99 ± 9.51; p < 0.0001; Fig. 5b ).

The differences in frequencies were highly significant (P<0.0001).

In the additional models by adding sequentially demographics, risk factors and markers of inflammation, HOMA-IR remained highly significant (all p < 0.0001).

This prognostic significance remained highly significant in both uni- and multi-variate analyses (HR: 0.14; CIs: 0.06-0.33; P <0.0001), emphasizing OMD status as a robust and independent positive predictor of survival in patients with metastatic colon cancer.

In total, 2 of 15 transient lineages carry longitudinally persistent and induced prophages, while 9 of 9 persistent lineages carry such prophages, and a Fisher’s exact test indicates a highly significant association between inducible phage and persistence of lineage ( P < .0001).

All fitted models were highly significant ( p < 0.0001), with R 2 ranging from 0.72 to 0.99.

The statistical analysis indicated a highly significant result (P < 0.0001), reinforcing the reliability and consistency of our experimental validation.

Copulsatility of the GH and GHRH hormone series was highly significant in both patients ( P < 0.0001).

The results showed that the model of K extraction recovery was highly significant, with F value = 47.06 and p -value < 0.0001.

After adjustment for age, gender, ethnicity and FMI, highly significant positive associations were observed between FFMI and CAL (p<0.0001) and with PRO, CHO and FAT (all p=0.0002).

The small subgroup of current smokers ( n = 4) showed a somehow peculiar profile, with highly significant changes in the expression of ICAM1 and NFKB1 ( p < 0.0001 and p = 0.002 respectively) and some other minor variations.

There was a highly significant negative correlation between the changes in PINP and BMD in lumbar spine and femoral neck from baseline to 12 months in all patients (r(s) = -0.68, P < 0.0001, and -0.45, P < 0.0001, respectively), and in pre- and post-menopausal patients separately.

The prevalence odds ratio for the association of K8/K18 mutations with human cirrhosis is 3.8 (95% confidence interval of 2.1–7.1), and the association with liver disease is highly significant when comparing a large American cohort of liver disease patients who underwent liver transplantation with a control group (P < 0.0001; Ku et al., 2005 ).