“highly significant”

We observed a highly significant correlation between the genetic distance and the variance (Pearson correlation coefficient: r = 0.773, n = 16, two-tailed p <0.0001), indicating that segregation increased in proportion to the genetic distance between strains.

When the eight single‐genotype variants were combined and compared against the WT parental virus treatment, there was a highly significant difference between the two types of virus treatments, that is multiple‐genotype WT vs. single‐genotype variants (treatment: χ 1 2 = 24·81, P < 0·0001), with the slope of the relationship between virus dose and virus‐induced mortality being steeper for the WT virus (log 10 dose × variant: χ 1 2 = 4·66, P = 0·025).

From Table 9 , it is evident that the model is highly significant ( P < 0.0001), while the lack-of-fit term is not significant ( P > 0.05).

Baseline global EP score and EDSS were highly significant predictors ( p < 0.0001) of EDSS progression 6 years later.

K S and the block size show a strong negative correlation, and Pearson's correlation coefficient is r = −0.288, which is highly significant ( p <0.0001, permutation test).

The difference in rates between officers and enlisted personnel was highly significant for hepatitis A, hepatitis B, and the aggregate of all forms of viral hepatitis (P < 0.0001) but was not significant for hepatitis, type unspecified (P = 0.099).

A highly significant in- crease in the number of tumors was ob- tained with the positive asbestos controls (p<0.0001) (Table 3).

There was a highly significant difference among the unirradiated groups compared to control Candida alone, with HSCO cells enhancing and HECV cells inhibiting the proliferation of Candida (p<0.0001 in both cases).

Importantly, multivariable Cox analysis demonstrated that CCNF remained a highly significant predictor of OS independently of histologic grade and TNM stage (HR 2.86, 95% CI 2.02–4.06, p < 0.0001; Table 4 ).

Allelic association tests yielded 93 highly significant SNPs (p < 10 -4 , corrected for permutation tests).

However when MT 0.5 mg/kg and 0.75 mg/kg were compared with 0.5 mg/kg midazolam [ Figure 1 ], the results were significant with MT 0.5 mg/kg ( P = 0.0407) and highly significant with MT 0.75 mg/kg ( P = 0.0001).

Repeatabilities (intra-class correlation coefficients, r 1 ) of FAs calculated from mammograms were calculated on a random sub-set of 20 mammograms from the study and showed highly significant r 1 values (repeated measures ANOVA, 20 sets of mammograms, FA breast width r 1 0.98, p = 0.0001; FA breast height r 1 0.86, p = 0.0001).

2 ), and this difference is highly significant (p = 10 -4 ).

Such an increase was slight due to the small size of malignant lesions but was highly significant in most experiments (e.g., in the AT-3 model at day 9 post-implantation, P < 0.0001; in the 4T1 model at day 9 post-implantation, P = 0.0029).

In addition to the previously reported QTLs on chromosome 16 (p<0.0001; 8), we found two highly significant QTLs (p<0.0001; Table 1 ; Fig. 1 ) on chromosome 5, one significant QTL on chromosome 2, (p<0.0001; Table 1 ; Fig. 1 ) and one suggestive QTL on chromosome 17 for USI trait (p<0.001; Table 1 ).

The degree of heterogeneity between the studies included in this meta-analysis was highly significant (p < 0.0001), as shown in Table 3 and Figure 2 .

Effects of Behavioral States and Pharmacological Interventions on Linear Heart Rate Measures Overall, highly significant differences were identified for HR (F 19,69.16 = 115.82; p < 0.0001) and SDNN values (F 19,68.74 = 44.04; p < 0.0001) between the experimental groups ( Figure 1 A,B).

Statistical analysis showed highly significant differences between Alström syndrome diabetic and young-onset type 2 diabetic patients with respect to presence of neuropathic symptoms ( P < 0.0001), absence of vibration perception ( P = 0.004), and mean lightest perceived monofilament ( P = 0.00001).

In contrast, highly significant effects of exposure duration were observed for all four molecules, and ethanol × exposure duration interactive effects were detected for mTOR and RPS6 ( p < 0.0001) ( Table 6 ).

A , In all cohorts, this correlation was highly significant ( p < 0.0001) with an R 2 = 0.83 in cohort 1, R 2 = 0.85 in cohort 2, and R 2 = 0.90 in cohort 3.

Differences in urinary cell counts between patients with active and non-active SLE were highly significant for CD3 + CD4+, CD3 + CD8+ and CD14+ cells ( P <0.0001) and to a lesser degree also for CD19+ cells ( P = 0.0137).

Furthermore, 2.40 MBq 90 Y-DOTA-DAB4 given 24 hours after chemotherapy produced a highly significant extension of MST to 61 days ( P <0.0001 versus control, and P <0.001 versus any other treatment including 2.40 MBq 90 Y-DOTA-7E11 given 24 hours after chemotherapy; Figure 6B ).

This analysis included > 300 families homologous to multi-pathway proteins and > 600 families homologous to other proteins, and revealed that the average frequencies of both insertions and deletions of the multi-pathway families were ~30% higher than those of others (insertions: 3.01 versus 2.42; deletions: 8.79 versus 6.29) (Additional file 4 ) and the differences were highly significant (P < 0.0001; T-test).

Surprisingly, however, the mutant mice showed a highly significant more rapid re-entrainment in 2.46 ± 0.26 days (F 2,27 = 18.8, p = 0.0001, day 1 = day of treatment, Figures 3 A–3C and 3G).

This finding was also clear for simulations on the directed AMBCA-based network when compared with the random directed network ( Figure 4B ), with a larger difference in predictive power (random − directed = −0.086), which was highly significant for unpaired ( p < 0.0001) and paired ( p < 0.0001) t testing.