“highly significant”

In ULMS, 3 miRNAs—miR-21-5p, miR-27b-3p, and miR-152-3p—had a highly significant underexpression ( p < 0.0001), and 4 miRNAs—miR-129-5p, miR-141-3p, miR-148a-3p, and miR-203a-3p—presented a significant overexpression ( p < 0.0001) (as seen in Figure 3 and Figure 4 ).

Furthermore, quantification revealed a highly significant ( P = 0.0001) fourfold reduction in the average number of Kyn + cells in D-1MT–treated animals ( Fig. 3 B ).

Whereas phagocytosis in the presence of heat-inactivated serum from NHD showed no significant association with LPC concentrations (not shown), a highly significant negative correlation ( r = –0.556, p < 0.0001) between LPC levels and phagocytosis in case of heat-inactivated serum from patients with SLE was observed (Figure 5 B).

Pairwise comparison between groups at each time revealed that all the test compounds induced a highly significant ( p < 0.0001) reduction in BGL comparable with the standard drug rosiglitazone.

4C ); and the differences in the correlations of the three groups were highly significant (P<0.0001).

All of these effects were highly significant ( P < 0.0001).

The statistical evaluation of compressive strength results, using one-way ANOVA ( Table 7 ), showed a highly significant effect of the mixture composition on mechanical performance (F = 28.83, p < 0.0001).

This observation was confirmed by the two-way PERMANOVA, which crossed swabbed region with health, stating that there were highly significant differences between regions and globally between health states (pseudo- F = 22.241, p -value = 0.0001, pseudo- F = 10.373, p -value = 0.0001, respectively) (Supplementary Table S1 ).

While the correlations between SPAD measurements and disease severity scores were highly significant ( P < 0.0001), they were relatively weak except for SM, which is a binary metric in which only disease severity levels of 1 (not affected) or 5 (severely affected) were observed.

Urea, ALT, AST and AFP were highly significant in post-hepatitic HCC patients than control group (P ≤0.0001).

The coefficient of the linear regression between pollen adhesion and fruit seed number was low, but again highly significant too (r 2 = 0.16; p < 0.0001; n = 105).

Strikingly, MC903‐treated obese animals had a 68.8% increase in ear thickness after treatment, which was highly significant ( p < 0.0001), compared to lean control animals (29.2% increase) (Figure 4B,C ).

This is a highly significant difference, as compared to the 49% de novo CNVs in vivo (p < 0.0001, binomial test).

The results indicate that plants in the SR at T12 exhibited the highest BC load (bcH) (1.94 × 10 06 ± 8.81 × 10 05 particles·mL −1 ) while plants in the RR at T12 exhibited an intermediate BC load (bcM) (7.26 × 10 05 ± 1.83 × 10 05 particles·mL −1 ), with a highly significant difference compared to the SR at that time point ( p < 0.0001).

The improvement in food intake in Group 3 and 4 was found to be highly significant ( P < 0.0001).

1 ) of both kidneys were greater in SCD patients as compared to controls, which was highly significant ( p <0.0001) for both the right and left sides.

ANOVA showed a highly significant effect of essential oil concentration and exposure duration on mortality rates ( p < 0.0001).

The results showed a significant enhancing effect of MEP in the affected hemisphere (SMD = 0.38, 95% CI = 0.02–0.74; P = 0.04) without heterogeneity ( I 2 = 0%) ( Figure 4(a) ) and a highly significant suppressing effect of MEP in the unaffected hemisphere (SMD = −0.83, 95% CI = −1.13 to −0.54; P < 0.0001), without significant heterogeneity ( I 2 = 18%) ( Figure 4(b) ). 3.3.2. rMTs in Both Hemispheres Four studies ( N = 121) [ 26 , 28 , 32 , 34 ] assessed the effect of LF-rTMS on rMT of the affected hemisphere by using the fixed-effect model that showed a large suppressing effect size (SMD = −1.00, 95% CI = −1.90 to −0.11; P = 0.03; I 2 = 79%) ( Figure 4(c) ).

The superiority of propolis was highly significant ( P < 0.0001; Mann-Whitney U test modified for superiority testing with a threshold 0.5 days; Figure 4 ).

Association between iNOS haplotypes and risk of malaria The Linkage Disequilibrium tests (LD) showed that the two polymorphisms of iNOS at position-954G/C and −1173C/T were in highly significant LD ( D ’ = 0.6648, r 2 = 0.4003, p < 0.0001) in the investigated subjects.

From day 2 onward, the differences in lengths between induced and uninduced mutants, measured using the Metamorph integrated morphometry analysis tool, were highly significant ( P ≤ 0.0001, Fig. 5B ).

However, there was a highly significant interaction between temperature and drought strategy ( F 1,124 = 41.77, P ≤ 0.0001), indicating that these groups of species responded to the experimental heat treatments differently.

Exact Kruskal-Wallis tests confirmed highly significant differences among non-treated and sphingosine (p < 0.0001) or ω–azido-C 6 -ceramide (p < 0.0001) treated N. meningitidis (Table 3 ).

The levels of serum NO levels showed highly significant correlation with saliva levels of NO in Group I ( r = 0.8607, P < 0.0001) as well as in Group II ( r = 0.9224, P < 0.0001) [ Table 4 ].

Of the seven SNPs, rs2240337 G>A was validated as an ESCC susceptibility locus, showing highly significant evidence both in heterozygote group ( p <0.0001) and homozygote group ( p <0.004).