“highly significant”

At both time points, highly significant increases in STAT6 phosphorylation (pSTAT6) (Fig. 3 b,c), as well as pSTAT3, was detected in both T cell subsets (p < 0.0001 for all) (Fig. 3 d–f).

Hypercapnia induced a highly significant increase in POBF values in NTG with a mean increase of 30.4% ( P = 0.0001) but little change was noted in controls whose mean change was 1.1% ( P = 0.7).

Two-sample t test showed highly significant group differences ( p < 0.0001) for all measures in both striatal regions ( Table 2 ).

As shown in Figure 4 B, PMA treatment induced a robust and highly significant increase in PKC activity ( p < 0.0001), validating that functional PKC is present and responsive in our membrane fractions.

The optical density (OD) of the test and negative control groups were 0.7 ± 0.02 and 0.01 ± 002, respectively, and their difference was highly significant (p = 0.0001).

The difference in mortalities among MPI score categories was observed to be highly significant ( P < 0.0001) [ Table 3 ].

There was a highly significant correlation, r = −0.54, p < 0.0001, between the α and τ parameters, such that the higher the modeled α , the smaller the modeled τ .

The frequency of IL-21 producing Tfh cells were highly significant ( p < 0.0001) in patients with acute dengue when compared with healthy individuals, where hardly any cytokine production was observed (Fig. 2 d).

rmANOVA regarding response time showed a highly significant main effect of order, F (2, 38) = 12.13, p ≤ 0.0001, but not regarding condition, F (1, 19) = 1.36, p = 0.26, as well as no interaction effect of order and condition, F (1.24,23.56) = 0.22, p = 0.7.

5b and D ) indicate that the HFS-fed rats and the rats in all of the treatment groups exhibited highly significant downregulation ( p < 0.0001) of adipose tissue PPARγ expression compared with that in the SD-fed rats.

The results of the one-way ANOVA showed highly significant differences between the different levels in each group ( p < 0.0001 for each group).

The correlation between the five categories was highly significant for pain relief (P <0.0001), though not significant for reduced dysfunction.

mansoni cysteine peptidases, leading to consistent and highly significant ( P < 0.0001) 50–83% protection of outbred mice against S. mansoni challenge infection ( 15 ).

We found a moderate but highly significant negative correlation between high SMAD1 expression and KEGG Apoptosis pathway inhibition across the ~ 1000 CCLE cell lines ( R = -0.1486, p < 0.0001) (Fig.

These results were highly significant ( p < 0.0001) compared to MT.

We found a highly significant overlap between genes that were positively correlated with USO1 across the B-ALL samples and downregulated in USO1-depleted cells (Hypergeometric test; p < 0.0001), but not in genes that were upregulated in USO1-depleted cells (non-significant p value) (Fig. 4 F, Supplementary 5C & 5D).

The combination of red LED irradiation with the compounds resulted in a highly significant ( p < 0.0001), dose-dependent reduction in Leishmania promastigote survival compared to the negative control ( Figure 1 B 1 –B 4 ).

Furthermore, matrine at 128 ng/mL had a very highly significant anti-BVDV effect compared to this extract at 4, 8, 16 and 32 ng/mL (P-value < 0.0001), and had a significant anti-BVDV effect compared to 64 ng/mL (P-value < 0.05).

This corresponded to a highly significant difference in both cold episodes and episode days of 61.1 and 72.9 % respectively ( p < 0.0001).

colemani in Spring Cucumbers A repeated-measures ANOVA revealed that the main effect of DACT was highly significant ( F = 219.78, df = 3, 1347, p < 0.0001), as was the interaction between treatment and DACT ( F = 53.97, df = 6, 1344, p < 0.0001), indicating significant temporal variation and treatment effects over time.

The Kruskal–Wallis test revealed a highly significant overall distribution difference among the three groups (A1, A2, A3) ( p < 0.0001).

Consistently, PERMANOVA indicated a highly significant strain effect ( pseudo -F 2,27 = 6.63, P = 0.0001), but non-significant effects for treatment ( pseudo -F 1,27 = 2.10, P = 0.054) and a strain:treatment interaction ( pseudo -F 2,27 = 1.62, P = 0.083). 3.3 Univariate analyses Consistent with the multivariate analyses, a linear model considering all proteins separately revealed that the abundance of 191 proteins (59.7% of total) was significantly affected (FDR-adjusted P < 0.05) by fish strain (Table S3).

First, we found a highly significant positive relationship between NDVI and soil moisture in the west kernel during January ( r = 0.736, P < 0.0001), indicating that a high NDVI is associated with greater water availability for winter plant growth and, as shown previously, with larger populations of herbivorous insects ( 38 ).

This was validated by ARS quantification, revealing a highly significant 6-fold increase in ARS concentration in the LT-Ti group compared to the SLA-Ti group (****, p < 0.0001; Figure 6 B).

The interaction effect between gender and housing density was highly significant ( P < 0.0001).