“highly significant”

The test clearly worked as it was supposed to as evident by highly significant differences in glucose levels with time ( p < 0.0001) in all groups analyzed (Figures 3 A–D).

This analysis included > 300 families homologous to multi-pathway proteins and > 600 families homologous to other proteins, and revealed that the average frequencies of both insertions and deletions of the multi-pathway families were ~30% higher than those of others (insertions: 3.01 versus 2.42; deletions: 8.79 versus 6.29) (Additional file 4 ) and the differences were highly significant (P < 0.0001; T-test).

We observed a moderate, but highly significant sensitization of cells after Jarid1A depletion with siRNAs A1+A3 as compared to untransfected (p < 0.0001) and control-transfected (p = 0.0025) cells ( Fig 4 ).

This relationship, expressed as R MZ /R DZ (considering bins with positive and significant R DZ ), shows substantial correlation (0.46–0.53, depending on chromosome) and highly significant ( P < .0001) correlation with R repeated ( Figure 2 ).

For example, the synaptic area in elav -Gal4,24B-Gal4/+ transgenic controls (380.82 μm 2 ) was dramatically expanded in neural and muscle combined-knockdown elav -Gal4,24B-Gal4<RNAi 42956 flies (526.82 μm 2 ), a highly significant ( P >0.0001) increase.

Baseline global EP score and EDSS were highly significant predictors ( p < 0.0001) of EDSS progression 6 years later.

Comparison of each MOI group to the control group showed significant (MOI 8: p = 0.0168) to highly significant (MOI 16–256, p < 0.0001) increases in the absolute number of BFP + cells/mm 2 ( Figure 5 c).

Regarding the HO-1d mRNA expression, a highly significant increase ( p < 0.0001) was observed in the liver samples of the old group compared to both the young and the treated animals ( Figure 1 c), while at the pulmonary level, this rise was not significant.

This analysis revealed a highly significant impact of the baseline value (p < 0.0001) and no impact for the group (p = 0.692).

The difference between these values is highly significant ( P < 0.0001).

The test for residual heterogeneity (QE) remained highly significant (QE = 125.38, df = 29, p < 0.0001), confirming that substantial heterogeneity persisted even after adjusting for the included covariates.

There were highly significant differences in mean aneuploid cells percentage between serous benign (1.5%), borderline (45.6%) and malignant (74.5%) (p = 0.0001) and between mucinous benign (13.2%) and both borderline (63.7%) and malignant (68.4%) groups (p = 0.0001).

Kaplan–Meier ‘survival analysis’ applied to freedom-from-tumors, followed by a stratified log-rank test for equality of survivor function showed a highly significant difference between the Keap1 flox/flox /Nrf2 +/+ and Keap1 flox/flox /Nrf2 −/− groups (χ 2 = 14.5; p < 0.0001).

In individual comparisons, the correlation value ranged from 0.85 to 0.98 and was highly significant in all the cases (P-value < 0.0001).

The difference between peak parasitemia following challenge of WT and PD-1KO mice was highly significant (p < 0.0001; Fig. 1b ).

The difference of distribution was considered highly significant ( p < 0.0001) ( Table 1 ).

A simple linear correlation was also found to exist between the products of lipid peroxidation (MDA), free radical scavenger enzymes (superoxide dismutase and catalase) and free radical scavengers (reduced glutathione); all these correlation were highly significant ( P < 0.0001).

According to the results of the variation analysis, it was determined that magnetic field intensity interaction was very highly significant ( p < 0.0001) on the DPPH value and the pellicle weight.

At the low and moderate doses (5 and 10 mg/L nCS), there was a highly significant increase in MDA content ( P < 0.0001) in all four examined tissues compared to the control group.

Mean duration of the maneuver (the time consumed since needle insertion until needle withdrawal) was 57 s in the first group, 02 m:07 s in the second group, and 03 m:03 s in the third group showing highly significant difference between three groups ( p -value < 0.0001).

The difference between p35S : cOBE3 wus-1/+ and empty vector wus-1/+ control is highly significant in both seedling and shoot stages (both Chi square, p<0.0001).

The most remarkable finding was a highly significant lower in-hospital mortality (56.8 vs. 88.1 %, p < 0.0001) in MET users despite a more explicit risk profile (diabetes, older age) and greater baseline disease severity (higher incidences of cardiovascular disease, acute kidney injury, and underlying malignancy) [ 1 ].

Moreover, 40 subjects with samples from two subsequent years showed a highly significant (p<0.0001) increase in cathelicidin concentration from visit one to visit two.

This difference was statistically highly significant (df = 1, n = 20 animals per group, log rank analysis, chi 2 = 22.73, Hazard ratio = 0.36, p < 0.0001).

Mean pain score was 3.14+1.19 in plastibell device group and 5.18+1.22 in bone cutter method and this difference was statistically highly significant (p-value <0.0001).