“highly significant”

For example, Subcluster002 with 99 nodes had none of the reported cell cycle genes ( Giotti et al., 2018 ), a highly significant departure from expected ( P = 7 × 10 –6 ).

DCN + TL) yielded a highly significant improvement in classification accuracy ( p = 0.000007, r = 0.81).

This resulted in a highly significant increase in the BAX/BCL-2 ratio in GH3 cells treated with 100 μM resveratrol compared to the ethanol control ( P = 7 × 10 −6 ) and the medium control ( P = 4.1 × 10 −6 , Figure 4D ).

For OS, only the biopsy variable could be added to the model (because of the problem of singular matrix decomposition), and it did not contribute to OS independently of grade ( p = 0.15), whereas a highly significant contribution of grade was confirmed ( p = 0.000007, Supplementary Table S2 a).

A total of 75 MTAs were associated with measured phenotypic traits under HNT, of which 24 were highly significant ( p ≤ 7E−06 to 9E−05), 20 were significant at p value = 1E−04, and the rest met a suggestive threshold ( p ≤ 2E−04 to 6E−04) (Supplementary Table S1 ).

Results The analysis revealed significant differential expression of MTFP1 and MTFP2 between tumor and adjacent normal tissues, with MTFP2 showing a highly significant upregulation (p-value = 7.06e-06) and an AUC of 0.698, suggesting its potential as a biomarker.

3 ) by Kruskal Wallis test applied to the difference between I 6 and I 1 (Δ (I6-I1) ) and observed a highly significant Hypnotizability effect ( p = 0.0000072) with the mediums’decrease larger than both highs’( p = 0.000019) and lows’( p = 0.000019).

This yielded a reduced list of 96 highly significant N-glycopeptides (99.99% confidence; p < 7.2e-6, after Bonferroni correction), still showing a complete separation between the healthy individuals and patients (PC1, 33.8% explained variance) and a significant separation between bacterial and viral infection (PC2, 7.9% explained variance) in a PCA score plot ( Figure 5 A).

As the global test of inflammation SNPs on hsCRP was already highly significant (P=7.3*10 -6 ), inclusion of additional SNPs, which were absent on the IBC CVD array, would not have changed our results for the global test, but may have revealed additional individual SNPs.

On two regions at ~ 3.3 Mb and ~ 32.8 Mb of chromosome 2 and two regions at ~ 6.3 Mb and ~ 8.5 Mb of chromosome 7, the highly significant associations of two SNPs (AJAPscaffold4_890918 with P = 7.31E−6 and AJAPscaffold1465_54665 with P = 6.15E−6) on chromosome 2 and two SNPs (AJAPscaffold2_603356 with P = 3.59E−6 and AJAPscaffold517_23072 with P = 5.44E−6 on chromosome 7 were detected for the trait, respectively.

The prediction performance for the natural varieties was highly significant ( R 2 = 0.52, p = 7.5 × 10 -6 , Figure 7a ), but not for the 2 knock-out lines that had a similar or even smaller predicted amylose ratio than their background varieties.

Genome size and introduction date We found that the average genome size of weed species is 47% smaller than that of nonweed species (3322.27 versus 6249.15 Mbp, respectively); this difference is highly significant ( P = 7.58E-06; Table S5).

We also found a highly significant relationship between PC1 scores and the pheomelanin marker (Spearman's ρ = 0.834, p -value = 7.6 × 10 −6 ), consistent with the fact that most of the variation in reflectance spectra between morphs is related to variation in pheomelanin content. 3.2.

When comparing the group of patients with “treatment support” by LHW with “no treatment support” patients, we found a highly significant difference between urban and rural locations (χ 2 = 20.03, p = 0.0000076).

While the large number of genes in the two Fd09 loci might reduce the probability of detecting significant enrichments, both Fd09 loci demonstrated enrichment for genes with potential immune functions, with highly significant enrichment ( P = 7.8e-6) for monoxygenase function in candidate locus 9.1, and the presence of multiple peroxidases in candidate locus 9.2, consistent with either a detoxification or ROS-based immune response.

In particular, LPC(16:0) had the highest VIP score (2.26) in the OPLS-DA model comparing cancer to NCE and were highly significant ( p = 7.8 × 10 −6 ).

Results showed that both SNPs that were significantly associated with HC in the two obesity sub‐cohorts exhibited highly significant associations (rs9661614 P = 7.9 × 10 −6 ; rs485660 P = 2.2 × 10 −6 ) that held after correction for multiple testing (rs9661614 FDR‐corrected P = 2.6 × 10 −4 ; rs485660 FDR‐corrected P = 1.4 × 10 −3 ).

Forced Cx43 expression reduced Bcl-2 protein level in each cell line, which was highly significant in FaDu ( p = 8e−06) cells ( Figure 4 B,C) but not in Detroit 562 ( p = 0.10) and SCC25 ( p = 0.57) cells. 2.5.

The differences between groups are highly significant statistically ( p = 0.000008; Table 2 ).

Individual time to antibiotic values are shown for every patient across all 3 periods in Figure 1 B, and the aggregate difference between successive periods is highly significant (Pre versus Post 1, P = 0.000008; Post 1 versus Post 2, P = 0.009).

6a ), the difference between the predicted drug sensitivity in multiple myeloma patients was highly significant ( P =8 × 10 −6 from a t -test) between trial-defined responder groups and non-responder groups.

The correlation analysis, which included genes spanning from low to medium-high abundance expression levels, showed a highly significant Pearson’s coefficient (r = 0.92, p -Value = 8.1 × 10 −6 ; see Figure S1 in the Supplementary Materials ). 2.3.

In particular, nucleotides within specific sites ( Figure 4 C; boxed regions) showed highly significant ( P < 8.218e-06) increases in susceptibility to acylation ex virio .

If we compare these results with those obtained with the BX2 , P(TARGET) GS lines ( Figure 3 ), the difference was highly significant (p=8.5×10 −6 , homogeneity χ 2 = 23.35 with 2 degrees of freedom, Supplementary file 8 ).

The repression of the promoter activity caused by 5-fC between 6 and 24 h post-transfection was statistically highly significant ( p = 8.6 × 10 −6 , Student’s two tailed heteroscedastic t-test), whereas the effect of 2′-( R )-fluorinated 5-fC was not ( p = 0.62).