“highly significant”

We found very strong evidence of association of multiple SNPs at TTC12 and ANKK1 in two different populations, EAs and AAs (minimal P=0.0007 in AAs and minimal P=0.00009 in EAs), and highly significant association of a single haplotype (set of markers) spanning TTC12 and ANKK1 to ND in the pooled sample (P=0. 0000001).

For 5 m bins, mound ID is highly significant ( p <10 −7 ) and distance is also significant ( p = 0.01), with density increasing on average with distance, but with much variation between mounds (no significant interaction effect).

Interestingly, of these 117 genes a clear degradation effect was observed with 94 genes displaying preferential loss of a 3′ probeset and only 23 genes showing loss of a 5′ probeset suggesting highly significant (P < 1 × 10 −7 , repeat random sampling) 3′ degradation.

Indeed, intersecting the positively correlated genes with all genes that encode for chromatin binding proteins, or epifactors ( https://epifactors.autosome.ru/ ), showed highly significant enrichment (Fig 4B , green, 44 genes, fold‐enrichment = 2.33, P < 10 −7 , Fisher's exact test).

In the Mushroom dataset, unlike SIPRI, the Friedman test detected highly significant ranking differences in all five metrics (all p < 10 −7 ).

Both infection history and history of probable traumatic stress exposure (categorized here as 0, 1, or 2 or more probable traumatic exposures) were found to be highly significant predictors (effect of COVID p < 1e-7, effect of trauma: p = .0001; Figure 1D ).

Additionally, a highly significant difference was observed in the β-cell function across the Chinese diabetic stages ( p < 0.0000001).

Combinations that we predicted to be anti-selective were indeed so, and this was highly significant when compared to the non-selective control combinations (Wilcoxon signed-rank test p < 10 − 7 , Figure 5 D).

Only SNPs mapped to the autosomes, with call rates > 0.98, minor allele frequencies > 0.03, and not in a highly significant deviation from the Hardy–Weinberg equilibrium ( P > 10 −7 ), were considered for the analyses.

These QTLR presented among the most significant associations in the first scan, and still harbor highly significant associations (p < 1e−7 and 1e−8, respectively).

As expected, there was significant enrichment of pathways involved in ‘bacterial invasion of epithelial cells’, ‘tight junctions’, ‘cytokine-cytokine receptor interactions’ and ‘colorectal cancer’; however, we also observed a highly significant association with ‘apoptosis’ (p<10 −7 ) ( online supplementary figure 6 ).

Our work also provides a list of 28 genes that are highly significant (p<10 −7 ) in all the three M1 stimuli and could be used as a starting point to define an agreed global M1 signature, when validated with other M1-polarizing agents ( e . g .

The binding profiles are extremely similar ( Figure 2 A), with a highly significant correlation between the two data sets (r = 0.586, p < 1 × 10 −7 , signal across genes).

Among 85 tissue cores with clear tumor and benign epithelium regions randomly selected for analysis, the difference in staining was highly significant ( P = 1 × 10 −7 ).

3 Discussion The first significant finding derived from this study is the clear and highly significant correlation between TD and response, with a response rate of only 9.1% for patients with TD <205 Gy against 89.7% for those with TD ≥205 Gy, P <10 −7 .

Further analysis of the gene set revealed a highly significant enrichment (p= 1.0 −7 ) for the upstream regulator hepatocyte nuclear factor 4 alpha (HNF4α), which regulates almost 200 genes (~ 15% of genes) in the list of differentially expressed genes between the two groups post-treatment ( Supplementary Table 1B ).

This positive coupling of both treatments was highly significant in a χ 2 -test of homogeneity ( χ 2 =29.6, degree of freedom=1, P <10 −7 ; Supplementary Table 5 ).

The Kruskal-Wallis rank sum test revealed a highly significant effect of feedback on rating (p<10 −7 ).

P i signal dropped faster than PCr increased during recovery (see Table 1 ); the correlation between the time constants τ PCr recovery and was highly significant ( r = 0.98, p < 10 − 7 ).

Regarding the favorability hypothesis, the combined effect of political climate was highly significant when the covariates were controlled ( Z = 6.68, p <.0000001) and when the covariates were not controlled ( Z = 6.45, p <.0000001).

These correlations are highly significant (binomial test P <1×10 −7 ).

If we obtain the average expression for all those RBRs and we compared it with the average for the HECT genes, the Pearson correlation coefficient for the expression values in the 79 tissues is positive and highly significant (r = 0.82, p<10 −7 ).

Twelve genes with highly significant cis -eQTLs (p-value<10 −7 ) contained tags that were regulated in opposite directions ( Table 3 ).

These changes could reflect changes in the training of those who name species, as more species are named by scientists who are not classically trained taxonomists or who have less familiarity with Latin and Greek; however, these hypotheses would be difficult to test. A notable feature of the etymological patterns in table 2 is that they vary among the surveyed taxa (and this variation is highly significant: p < 10 −7 ).

The relationship between Cl and BW was also highly significant ( P = 10 –7 ), but the change in Cl as a function of BW is somewhat flat, as the PWR exponent was only 0.15.