Barely Significant
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“fell just short of statistical significance”

126 sentences · 126 papers · 142 search hits before verification · confirmed specimen

Sighted at

p=0.12

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Initially the pharmaceutical company ‘ran the numbers without those nine, and the result fell just short of statistical significance, at which point eight of the subjects were added back into the analysis, improving the statistics enough to make the results significant—the problem was later hidden in the submission to the FDA ... ’ 41 .
In univariate proportional hazards models stratified by baseline liver fibrosis stage (0–1 and 2–3), UCSF treatment nonresponders showed an increased hazard for developing cirrhosis when compared to the never treated group, but this result fell just short of statistical significance (HR = 2.28, CI 0.93–5.59, Table S3 ).
At the time of these initial approvals, results of only two randomized placebo-controlled trials were available: a prematurely terminated and underpowered study by Wang et al., which found no statistically significant effect of remdesivir on time to clinical improvement or mortality rate [ 5 ]; and NIAID’s ACTT-1 trial, which found a statistically significant shorter time to clinical improvement in the remdesivir group, while the effect for mortality fell just short of statistical significance [ 6 ].
The estimates derived from the inverse probability weighting model for descending transition patterns remained statistically significant, with ORs of 2.2 (95% CI 1.32, 3.79) for maternal overweight at pre-pregnancy, 3.89 (95% CI 1.25, 12.06) for infant overweight at time 1, 4.16 (95% CI 1.40, 12.28) except for maternal educational history, which had an almost identical estimation but fell just short of statistical significance (OR 1.12; 95% CI 0.99, 1.26).