“borderline significant”

Sensitivity Analyses and Publication Bias As we had mentioned above, studies of patients with DIS and DMS symptoms reported borderline significant heterogeneity.

Among the remaining RA patients two years after initiation of the study, 25 (38%) had non-erosive disease and 13 (20%) had erosive disease ; Baseline C2M concentrations were slightly higher in patients with erosive disease (0.23 ng/mL (0.19–0.26)) compared to patients with non-erosive disease (0.18 ng/mL (0.15–0.22) as a prognostic outcome (p = 0.011), this difference was borderline significant when adjusted for multiple testing, with the highest (median (IQR)) concentration in the erosive group and the lowest concentration in the non-erosive group.

The LLV and CCL2/MCP‐1 interaction was borderline significant, while the interaction between LLV and CD163 was statistically significant in the association with hypercholesterolemia (Figure 4 ). 4 DISCUSSION In this longitudinal study of ART‐experienced PLWH, we found that pLLV was associated with an increased risk of developing NCDs.

Previously the human TP73 gene was described as having borderline significant association with AD in a small dataset and that decreased p73 expression occurs in some cases of AD [ 23 ].

A significant reduction in FBG and HOMA-IR was found in the studies with various whole grain products while whole grain products only had a borderline significant effect on FBG.

noticed a borderline significant increase in the membrane staining from primary lesions to lymph nodes and distant metastases [ 62 ].

When considering the pan-macrophage CD68 marker, the differences in densities were nonsignificant between all groups within each zone, except for the borderline significant difference between the wine and ethanol groups in the peri-infarct zone ( Figure 4 and Figure 5 ).

Our results from the MR analysis revealed a borderline significant association between AIF and the risk of urolithiasis.

Among healthy overweight subjects on a weight-reduction program, and receiving vitamin D (83 μg/d) or placebo for 12 months, a borderline significant reduction in TNF-α concentration (−10% in the treatment group versus −3% in the placebo group) was recorded [ 80 ], although this finding was not replicated in subsequent studies [ 75 ].

Lastly, Hsieh et al [ 33 ] used the Centre for Epidemiologic Studies Depression Scale (CES-D; 0–3 Likert with a cutoff score of 15), the Resilience Scale (1–7 Likert), and the Occupational Stress Indicator-2 (OSI-2; 1–5 Likert), resulting in borderline significant depression (mean CES-D total score, 14.96), high occupational stress (mean the Resilience Scale score, 5.18), and a low level of resilience (mean OSI-2 score, 1.55).

Similarly, the unadjusted model for ICI showed a significant association with mortality (HR = 1.08, 95% CI: 1.00–1.17, p = 0.052), suggesting that a heightened inflammatory and hypercoagulable state at admission elevated death risk, though this was borderline significant.

Moreover, multiple linear regression model showed a negative association of disease severity with PF, RP, GH, and PH dimension and a borderline significant association with total SF-36 score.

One study carried out among CHB patients with high HBV DNA viral load (> 6 log 10 IU/ml) reported that TDF treatment was associated with a higher incidence of acute kidney injury (AKI) compared to ETV, but this difference was only borderline significant after three years follow-up [ 16 ].

In the crude analysis, a borderline significant association between being in student/mixed groups and asthma was seen with OR 1.05–1.08, but without confirmation in model 1 or 2.

In the multivariate model (data not shown in table), education became significant (OR: 8.68; 95% CI 1.03–72.75) while ethnicity remained borderline significant (OR: 2.33; 95% CI 0.93–5.86).

It is also important to note that borderline significant correlations were obtained between the ability to engage in reflective thought (as measured by the CRT- Reflective score) and the buildings task change score ( r = 0.111, p = 0.053) and the cars task change score ( r = 0.104, p = 0.088).

Age was the only variable showing a borderline significant association with overall complications.

In the non-ACO group, some differences were found between two hospitals before PS matching: significantly more patients received adjuvant chemotherapy in the K hospital (65.0%) than in the R hospital (46.2%) (p < 0.001); tumor location and the R status also showed borderline significant.

The results of our previous study investigating SMRP as a tumour biomarker for MM, showed significantly higher SMRP levels before treatment than the levels in complete response, partial response, and a borderline significant difference between levels before treatment and stable disease. 12 These findings suggest SMRP not only as a superior diagnostic biomarker for MM compared with fibulin-3 as presented in the study of Creaney et al . 26 , but also as a superior biomarker for evaluating tumour response to treatment.

Heterogeneity analysis For the LAPC series, 1-year, 2-year and 3-year OS rates, 1-year PFS rate, the incidence rates of acute GI and hematologic toxicities (grade≥3) demonstrated significant or borderline significant heterogeneities among the studies.

A study on COVID-19 among many patients older than 60 years old also revealed a borderline significant association between age and time from initial symptoms to death, confirming that critically ill patients are more likely to be older ( 22 , 23 ).

There was only a borderline significant overrepresentation of mutations in PPM1D among participants with an ICU admission or an in‐hospital death.

Multivariate analysis demonstrated a borderline significant sociodemographic variable relationship between baseline non-compliance and COG-1 as well as COG-2.

There was a significant or borderline significant main effect of depressive states in seven n-3 PUFAs, excluding n-3/n-6 PUFAs ratio and n-6 PUFAs.

We observed significant interactions of glucose control status with Yang and Yin deficiency (p for interaction = 0.0363 and 0.0379, respectively) and borderline significant interaction of glucose control status with phlegm stasis (p for interaction = 0.0641) ( Figure 2 ).