While there was a trend and a borderline significant difference in 30-day mortality between PSI and CURB-65 ( p = 0.0 9 , FDR-corrected), there was no significant difference in in-hospital mortality, which is similar to past studies [ 36 ].
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The subjects presented with a 34% increase in STM score after the exercise program, while control subjects with a 17% lower score after exercise.[ 30 ] Association between an increase in right hippocampal volume and improved performance of the Rey Memory Test (rho < 0.23; P < 0.10) was borderline significant.[ 33 ] Resistance programs on functional ability exhibited significant time effects (F (2, 7.791) =32.638; P = .000) in the GAF, with an improvement in scores over time.
We found loci with genome-wide significant associations to EPDR1 expression in human islets (rs6965395 and rs1524054) and others that were borderline significant (rs4720265, rs3734952, rs10488617 and rs3213975 with nominal p-values = 2.5 × 10 −21 , 7.14 × 10 −21 , 4.5 × 10 −22 , 4.5 × 10 −22 , respectively).
We found 11 other associations, 8 in DLPFC and 3 in hippocampus, all borderline significant except CENPM (p = 2.4e-12) and EFTUD1P1 (p = 2.8e-05) for eQTL, and the “GNL3 , SNORD19 , SNORD69 , SNORD19B” region (7e-04) for aeQTL.
Variants in NEAT1 demonstrated borderline significant associations with ALT ( p = 1.9 × 10 −11 ) and HbA1c, but not with liver fat, as well as influencing waist‐to‐hip ratio, adjusted for BMI.
GWAS Genome wide association analyses of IL-10 levels ( S3 Table ) resulted in one highly significant peak on chromosome 9 in the ACS patient cohort (top SNP: rs676457, P = 4.44*10 −10 ), and another borderline significant SNP on chromosome 6 in the healthy controls (rs11961593, P = 1.80 × 10 −7 ) ( Fig 1 ).
When the analysis was stratified by gender, one additional SNP (rs549485) located about 350 kb apart from the SAA1 subregion at 11p14 in the secretion regulating guanine nucleotide exchange factor ( SERGEF ) gene showed a borderline significant association with A-SAA levels in men (p = 2.76×10 −8 ) in the meta-analysis.
Only a borderline significant association was found between PGS p < 5 × 10 −8 for diabetes and sural SNAP amplitude (β = −0.25, 95% CI = −0.52 to 0.02; Table S1 ).
Notably, miR‐142‐3p expression is one of the miRNAs that is significantly increased by chronological age in peripheral blood [ 8 ] and an MIR142 ‐proximal genetic polymorphism (rs2632516) was borderline significant for late‐onset Alzheimer's disease in a genome‐wide association meta‐analysis ( p = 5.3 × 10 −8 ; genome‐wide significance at 5 × 10 −8 ) [ 9 ].
rs6483495, an intronic variant of MAML2 located at 11q21, showed the borderline significant p -value (Beta = −0.14, P = 5.4 × 10 −8 ) (Fig. 2b and Table 2 ).
9 A previous study also reported a borderline significant association of the variant rs429358, representing the APOE ε4 locus with PD-AAO ( p = 5.69 × 10 −8 ) in a combined dataset (n = 28,568) comprising IPDGC and 23andMe datasets. 7 The study, however, suggested that the association at the locus could be an age-related effect, with a highly significant association with the age of controls ( p = 1.49 × 10 −5 ).
While rs138740 did not replicate, it remained borderline significant (meta-analysis P =5.7 × 10 −8 ) when the discovery and replication sets were combined and we observed effects in the same direction as in the meta-analysis (OR=1.04–1.08; Table 2 ).
In contrast, three borderline significant SNPs in the PLEKHA8 gene (rs11982167, rs11975522 and rs11773644) associated with NR3C1 gene expression ( P = 6.44 × 10 −8 ) showed weak evidence of association with Pred sensitivity ( P = 4.92 × 10 −2 ).
East Asian meta-analysis only found a borderline significant single-variant association (rs12530098 with the lowest p value; OR=1.10, p=6.9×10 –8 ).
Although no other SNPs reached genome-wide significance in the conditional analysis, a few borderline significant signals emerged: rs191288953 ( p =7.41E-08; chromosome 7; closest gene SDK1 ) and rs79935880 ( p =7.69E-08; chromosome 10; near MTRNR2L7 ) for C22:0 ceramide levels and rs34432959 ( p =8.68E-08) and rs12963655 ( p =8.00E-08) for C24:0 ceramide levels, both of which are located near SYT4 on chromosome 18.
An additional locus was borderline significant ( P = 8×10 −8 ), but was externally validated.
CD, MOSGWA selected 14 SNPs, including rs17659990 (P=5.43×10 -9 , DOCK3 ) that reached the generally accepted level of genome-wide significance, followed by borderline significant rs7742915 (P=8.52×10 -8 , BTBD9 ), rs16944613 (P=1.49×10 -7 , CRTC3 ), rs13129679 (P=2.38×10 -7 , RNF4 ) and rs12953717 (P=3.00×10 -7 , SMAD7 ), a well-known CRC susceptibility variant.
Although none of the 12 SNPs reached genome-wide significance ( P = 1.17 × 10 −7 ) in this validation analysis, SNP rs13720 exhibited a borderline significant association with progression to jaundice stage (OR = 2.15, 95% CI = 1.61–2.87, P = 1.36 × 10 −7 , Table 2 ).
Results For EA, rs13429103 at chromosome 2p25.1, near the RNF144A-LOC339788 gene, showed a borderline significant interaction with smoking status ( P = 2.18×10 -7 ).
Meta-analysis of SNPs common to all four GWAS ( N = 6661818 and N = 6496414 for all AML and cytogenetically normal AML, respectively) also revealed additional borderline significant susceptibility loci at 1p31.1 (rs10789158, CACHD1 , P = 2.25 × 10 −7 ) for all AML and at 7q33 (rs17773014, AKR1B1 , P = 4.09 × 10 −7 ) for cytogenetically normal AML, both with consistent direction and magnitude of effect across all four studies (Figs. 1 and 2 ).
Multiple CpGs reaching genome-wide significance (FDR < 0.05) were found for E2 (87 CpG sites, corresponding p value < 8.36e-06, Supplementary Table S2 ); for PRL (199 CpG sites, corresponding p value < 2.02e-05, Supplementary Table S3 ); and borderline significant for P (3 CpG sites, FDR = 0.06, corresponding p value < 4.30e-07, Supplementary Table S4 ).
A further four SNPs were borderline significant for EM ( P < 5 × 10 −7 , Supplementary Material, Table S2 ) and two of these had not been previously identified in the QT GWAS: rs1867631 in SGIP1 at chromosome 1p31.3 and rs1473307 near NYAP2 at chromosome 2q36.3.
Results In the GEE models, borderline significant association was observed at 3 chromosomal regions (6q15: rs284515, p = 6.6x10 −7 ; 6q27: rs75908454, p = 6.3x10 −7 and 10q25.3: rs1679568, p = 8.1x10 −7 ), extending to numerous SNPs in linkage disequilibrium (LD) across each region.
Assessment of API5 revealed a significant association with body mass index (BMI) and a borderline significant association with neutrophil count ( p -value = 9 × 10 −7 ).
GARFIELD reads variants from our GWAS summary statistics using two p -value thresholds: genome-wide significance ( p = 5 × 10 −8 ) and borderline significant ( p = 1 × 10 −6 ) in its analysis.