Barely Significant
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“borderline significance”

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borderline significancep = 0.0601.2× alpha
In the multivariate analysis, only age (4% risk increase) and preoperative diastolic ABP (risk decrease of 6% with higher diastolic ABP) remained significant; however, incidental diagnosis showed borderline significance (2.8-fold risk increase; p = 0.060).
borderline significancep = 0.061.2× alpha
Primary endpoint The meta-analysis of pooled hazard ratios in all trials, including a total of 1789 patients, showed that all-cause mortality in the ICD group decreased with borderline significance (167 of 886 patients, i.e. 19%) in comparison to optimal pharmacological treatment (195 of 895 patients, i.e. 22%), with a HR of 0.48 (95% CI 0.67–0.10); p = 0.06; heterogeneity p = 0.78; I 2 = 0% ( Fig. 2 ).
borderline significancep = 0.061.2× alpha
Interestingly, secondary analysis of data from a study of van Grootven and colleagues [ 47 ] revealed that among 86 patients aged 80 ± 7 years undergoing orthopedic surgery, the lowest intraoperative diastolic BP was the protective factor for POD (OR = 0.92; 95%CI 0.85–0.99, p = 0.03) and the protective impact of the highest systolic BP was of a borderline significance (OR = 0.97; 95%CI 0.94–1.0; p = 0.06).
borderline significanceP = 0.061.2× alpha
Carriers of the rs4149601 GG-genotype together with the rs2288774 CC-or CT-genotype, as compared to non-carriers of this combination, displayed significantly lower P-renin and borderline significance for systolic salt sensitivity (P = 0.06–0.08) whereas there was no significance in diastolic salt sensitivity and Nt-proANP ( Table 3 ).