“borderline significance”

A recent meta-analysis of five prospective studies showed a higher (with borderline significance) predictive value of central as compared with peripheral PP, although central and peripheral PP were not measured simultaneously under the same conditions in all studies included in the analysis. 18 Accordingly, Wang et al showed that when central and peripheral systolic pressure were both included into a regression model, only central pressure remained significantly related to cardiovascular risk. 19 Moreover, BP-lowering drugs can have differential effects on central aortic pressures and hemodynamics compared with brachial BP.

However, with assumption of the borderline significance at level 0.05, statistically significant results in discriminating between all study groups were obtained for volumetric measurements of the right hippocampus and the right entorhinal cortex.

In addition, older age showed a borderline significance for higher pruritus intensity.

BU063 has an intermediate measured abundance and less association with disease, with the metatranscriptomic data not showing a significant difference and the 16S data having borderline significance.

We found a signif- icant prognostic influence of nuclear p53 protein expression when only tumour variables were investigated, whereas p53 staining showed a borderline significance in the multivariate analysis with FIGO stage included.

Sex showed borderline significance, whereas KPS, tumor size, preoperative epilepsy, and Ki-67 were not significantly associated with OS.

2 , 5 , 7 , 9 The borderline significance of subdural effusion in the PEEK group warrants further investigation with larger cohorts to assess potential clinical implications.

Correcting for multiple testing using q-values based on Benjamini, Krieger, and Yekutieli (2006) [ 24 ] did not change any of the conclusions about statistical significance; corrections using q-values based on Benjamini and Hochberg (1995) [ 25 ] did not change conclusions for six out of seven statistically significant impacts reported and showed borderline significance for the seventh (minimum meal frequency: q = 0.0519).

Analysis of serum drug concentrations (see supplementary table S7) revealed a borderline significance between tacrolimus levels and a marked reactivation of polyoma virus, with/without PVN.

For rs731236 in overall meta‐analysis (based on minor allele; t) no significant result for the risk of CRC was observed, but in subgroup analysis in Middle East population the results were significant in heterozygote (Tt vs TT) (0.76 [0.61‐0.95]) and overdominant models (Tt vs TT + tt) (0.75 [0.61‐0.92]), and borderline significance was observed in dominant model (tt + Tt vs TT) (0.81 [0.66‐1.00]) (Figure 2 , Figure S2 ).

Although between-group comparisons did not show statistical significance, baseline-adjusted ANCOVA revealed a borderline significance for TNF-α, suggesting a potential anti-inflammatory effect of LL supplementation.

Performing the same analysis in patients with TP53 mutated tumours all receiving adjuvant chemotherapy (n = 19), there is a borderline significance toward better prognosis for patients with higher expression of the gene. 3.4 Target gene search within specific gene expression subtypes The presence of TP53 mutations is one possible way of identifying subgroups for target gene search.

The borderline significance of the genotype effect was due to high variability in this behavior at 7-months (Figure 3 E).

Moreover, the frequency of depression was higher among nintedanib users with borderline significance, which indicated that depression could be the reason for drug discontinuation in nintedanib users.

On the other end, pyrimidine and purine metabolism show borderline significance in the analysis; however, their roles are crucial because purine and pyrimidine salvage pathways are well established in cancer, supplying the necessary building blocks for tumor cells to perform DNA and RNA synthesis [ 13 , 14 ].

Variables for which the difference in PTDR was identified above borderline significance were age, type of hospital, transfer y/n, time from accident to death, and RTC y/n.

In addition, it was suggested that rosiglitazone may be associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes that had borderline significance [ 38 ].

On the other hand, HF, CKD, and atrial fibrillation were shown to have borderline significance with similar ORs.

Removal of this study from the pooled analysis reduced heterogeneity to borderline significance (I 2 51% [95% CI 0–78%]; P value, test for homogeneity 0.05).

Furthermore, we found a non-linear association between insulin resistance and pulmonary function in FVC and borderline significance in FEV 1 , but not in FEV 1 /FVC ratio.

Lung function and asthma phenotype When comparing the asthma groups with the never asthma group (reference) regarding post-bronchodilator lung function at 24 years, FEV 1 was lower in both males and females with childhood asthma in remission and males with persistent asthma, with borderline significance for females ( table 3 ).

One study found that replacement of 8 E% SFA with MUFA resulted in a lower CRP concentration with a borderline significance ( 61 ), whereas in another study no difference between the SFA period and the MUFA period was found ( 23 ).

In Phase 2, age ≥65 years remained significantly associated with moderate II or higher disease across all models, antipsychotic use showed a robust positive association, and the effect of aspiration pneumonia was strong in unadjusted models but attenuated to borderline significance after multivariable adjustment.

Using univariate logistic regression analyses the following variables were associated with BK viral replication (Table 3 ): ESP recipient status, recipient age, prior biopsy proven acute rejections (BPAR), lack of participation in prospective clinical transplant trials, mode of renal replacement therapy prior to transplantation, previous transplantation, donor (IgG -) as well as recipient (IgG +) CMV-serostatus, LDL-cholesterol, and - with borderline significance - 25-hydroxy vitamin D level.

We repeated the analyses using the difference (as opposed to absolute difference) between near and far IVF, and similar results were found (with now borderline significance for “crossing the street” and “feeling vision is fuzzy or blurry”; data not shown).