“borderline significance”

The results from the case-control studies indicated a significant protective association between aspirin intake and a reduced risk of primary skin cancers, while the results from the cohort studies indicated only a borderline significance in the protective effects of aspirin intake against skin cancer.

Age ≥ 60 years (hazard ratios 3.17–10.1 vs < 50 years), > 2 comorbidities (1.41 vs ≤ 2), acute myeloid leukemia (2.22 vs non-Hodgkin lymphoma) and active antineoplastic treatment with monoclonal antibodies (2·02) were associated with increased mortality; conventional chemotherapy showed borderline significance (1.50 vs no active therapy).

However, in contrast to a recent investigation in anal carcinoma treated with definitive RCT ( 22 ), we did neither recognize a significant correlation of p16 INK4a with PLK3 and a borderline significance with pT273 Caspase 8 expression ( Table 2 ), nor did we observe a significant impact of PLK3 and pT273 Caspase 8 detection on the incidence of local failure ( Figures 2 , 3 ).

Age was not found to be significantly associated with visual field scores, although the association between age and physical activity level approached borderline significance.

However, the borderline significance observed in this study may indicate the need for larger sample sizes or more nuanced classifications of control to more robustly assess the impact of maternal glycemic management on neonatal outcomes ( 22 ).

The t -value was 2.0 and P = 0.052, giving borderline significance.

Correlations between HTATIP2 expression/microvessel density and clinicopathological features As shown in Table 2 of cohort 1, patients with a low intratumoral HTATIP2 expression or a high MVD were prone to exhibit large tumor size, high serum α-fetoprotein concentration, high tumor-node-metastasis (TNM) stage (borderline significance for HTATIP2), and the presence of intrahepatic metastasis and microvascular invasion.

There was also a borderline significance difference in respect of clinical staging with fewer patients with advanced tumours making use of the PCI.

The results showed minimal lipid changes (<5 %) with borderline significance, confirming that medication use does not impact our conclusions.

The borderline significance might be due to the sample size within the metastatic subgroup or the strong influence of other factors in the model.

There was a borderline significance between adEV size and TAG/HDL-C ratio in the univariate model, but when the other measures of general or visceral adiposity were included, the relation did not reach significance.

In the present study, baseline IOP with the borderline significance and the IOP measured at OCTA exam with substantial significance were found.

Baseline Ang-2 levels showed borderline significance with PFS and OS.

Results Moderate maternal pre-parturition fish intake (1 to 4 times a month) was, at borderline significance, associated with a lower risk of wheeze (adjusted OR = 0.69 (0.45-1.05)) before age 2, compared with low intake (< once/month).

On the other hand, the non-porous silicone implant had a borderline significance with an OR of 4.14.

A p -value of > 0.05 to < 0.1 was considered as borderline significance in this study.

For the renal tumour survivor group as a whole the probability of miscarriage was also increased, reaching borderline significance (OR 1.9, 95%CI 1.0–3.5).

Further, each pair of bacterial species selected from the ML algorithm to predict each mAA was also found to be statistically significant with each of the mAA ( P = 0.016–0.049), except for Bdellovibrio bacteriovorus ( P = 0.062) for Horvath that had borderline significance.

On multivariate analysis, we found that age at diagnosis, sex, tumor differentiation grade, lymph node metastases, and surgical treatment were independent risk factors for prognosis ( P < .05, Table 2 ), whereas both tumor size ( P = .064) and marital status ( P = .051) had borderline significance (Table 2 ). 3.3.

Systemic delivery gave an inverse U-shaped relation, with borderline significance with the lower dose (<1.5 M cells), a larger effect size with 2–4 M cells and less efficacy with higher doses.

Chemotherapy and radiotherapy In contrast to other solid malignancies, chemotherapy plays a limited role in the treatment of advanced HCC, except that oxaliplatin plus fluorouracil/leucovorin (FOLFOX4 regimen) was found to prolong patient survival with borderline significance compared with doxorubicin. 45 As summarized in Table 1 , chemotherapy with capecitabine, tegafur/uracil, or epirubicin plus carmofur were investigated as adjuvant treatment; however, all of them failed to prolong patient survival and only capecitabine was found to prolong patient RFS.

< 5.6 mmol/1) had an increased risk of CRC with borderline significance (HR = 1.19, 95% CI: 0.96–1.48).

We found no effect of magnesium treatment on an extensive explorative panel of circulating inflammatory proteins, although hsCRP levels were numerically lower after magnesium supplementation compared with placebo with borderline significance.

However, the effect estimates are imprecise in both studies, with borderline significance on the lower end of the confidence interval caused by small sample sizes.

Both clinical and mouse studies suggest that females may be at higher risk of ICI myocarditis, but the literature on sex disparities in ICI atherosclerosis is more equivocal, limited by small sample sizes or borderline significance [ 32 , 33 , 157 , 158 ].