“borderline significance”

Thus although they were not considered significantly associated with breast cancer at the defined cutoff, their borderline significance with breast cancer risk and consistent association with breast density warrant further investigation of these SNPs in relation to breast density and breast cancer risk.

Subgroups differed significantly between gestational age at delivery and newborn weight and with borderline significance between age and PAPP-A.

Below in section 4, we further discuss how the NOWAC postgenome cohort gives a unique opportunity to stratify patients by their tumor molecular subtypes, which may give more power to the classical case-control studies to identify genes of no or borderline significance for breast cancer as such, but which may be more highly penetrant for certain subclasses.

Univariate Cox regression analysis identified higher SSIGN (The stage, size, grade, and necrosis) score and decreased ipsilateral SRF as significant risk factors, while multivariate analysis showed SSIGN (5–7) (hazard ratio [HR] 11.9, p < 0.001) and SSIGN (8–10) (HR 69.2, p < 0.001) were significantly associated with shortened DFS, while decreased ipsilateral SRF (HR 1.75, p = 0.065) showed borderline significance.

Again, the G allele was more common in IDU-HIV-1 infected compared to IDU-HESN with a borderline significance of 0.064.

Both higher resistin and sST2 levels predicted higher rates of all-cause mortality and MACEs in the patients with CAD during long-term follow-up, but not WGRS of RETN and IL1RL1 variants, except a borderline significance of low RENT WGRS on all-cause mortality.

Despite the fact that these associations became weaker after adjusting for other variables (depression maintained borderline significance), they still suggested that by reducing the psychological distress and improving the psychological well-being of the participants, the perception about accessibility to medical care improves [ 35 ].

Our study revealed significantly higher values in men of Tpe/QT in leads V1, V2, V6, and mean and maximum Tpe/QT, with borderline significance for Tpe.

There was also a significantly increased AOR for maternal underweight and borderline significance for overweight categories.

We applied chi-square and logistic regression analyses to adjust for this imbalance; however, we advise interpreting the findings with borderline significance cautiously.

In this analysis, young age was still an independent significant prognostic factor while hormone therapy showed borderline significance (Table 4 .).

Several other SNPs showed borderline significance including SNPs in intron 1 (rs2286960, protective(P)) and in the 5'region i.e . rs344779(-3666, P), rs11668247(-20040, P) and rs346054(-30147, P).

Similarly, the risk of all-cause mortality was also increased in the lower DCIs and lower DEIs group (HR 1.41; 95% CI 1.00, 2.00), reaching borderline significance.

Significant prognostic predictors were identified, including PG-SGA symptom assessment (HR = 1.068, 95% CI: 1.001–1.131), disease status (HR = 2.054, 95% CI: 1.551–2.721), and GLIM handgrip strength (HGS, HR = 1.424, 95% CI: 1.175–1.725), while food intake showed borderline significance (HR = 1.124, 95% CI: 0.999–1.264).

These regression models showed that praziquantel still had an efficacy similar to that of surgery, but some of these results actually showed borderline significance and indicated a tendency toward a surgical benefit.

However, the P value showed borderline significance; furthermore, if the children were subcategorized by the average hours of sleep (>7, 6‐7, 5‐6, and <5 hours), no significant difference was found across any subgroup between supervised and unsupervised children.

The cohorts treated with anti-CD19 drugs had higher odds for all-grade (OR, 2.7; 95% CI, 1.0–7.7; P = 0.057) ICANS than cohorts treated with anti-BCMA drugs, with borderline significance.

Discussion In the current study, we observed a positive trend for higher risk of breast cancer incidence across increasing TV viewing time categories with a borderline significance among total women and reached a level of significance among postmenopausal women after adjusting for physical activity and other potential confounders.

- The interpretation of OR 1.53 (95%CI 1.00-2.33) for females should be approached with caution as the lower bound of the confidence interval is exactly 1.00, suggesting borderline significance. - There is a problem in Smartphone ownership data percentage. 198 out of 218 would be 90.8%, not 93.6%.

The type of resection performed (wedge resection versus greater resections) showed a borderline significance.

found that MRD positivity at day 100 was the strongest prognostic factor for relapse and survival, whereas mixed CD3 chimerism showed only borderline significance. 22 Similarly, Loke et al. demonstrated that MRD positivity after transplant conferred more than twice the hazard of death (HR ~2.2) and remained significant in multivariate analysis regardless of pre-transplant MRD status. 23 These concordant findings solidify post-HSCT MRD as a more robust and clinically relevant predictor of relapse than chimerism analysis.

However, there appeared to be a flattening of the inverse relationship at approximately 70 h/wk for CHD ( P non-linear = 0.01) and heart failure ( P non-linear = 0.06), despite of a borderline significance for heart failure possibly due to low number of cases.

Large tumor size ( P = .053, HR 1.356, 95% CI 0.996-1.845) and advanced FIGO stage ( P = .071, HR 8.018, 95% CI 0.834-77.124) showed borderline significance.

In a Cox multivariate analysis including clinicopathologic variables, PCAT14 stands out as a significant independent predictor of PSS ( P = .0385; HR = 0.55 [0.31–0.97]), MFS ( P = .000609; HR = 0.52[0.36–0.76]) and BRFS ( P = .00126, HR = 0.64 [0.49–0.84]), with borderline significance for OS ( Table 1 , Supplementary Table 3 ).

Waist circumference showed borderline significance after adjustment, while outcomes that were non-significant in the primary analysis remained non-significant.