Barely Significant
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“at the threshold of significance”

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In the literature

Associations between BMI and CSF AD core biomarkers and cognitive function In all participants, MLR models showed that continuous BMI variables were negatively correlated with the concentration of CSF P-tau (β = −0.29, p = 3.76 × 10 −5 ), T-tau (β = −2.51, p = 8.53 × 10 −5 ), P-tau/Aβ 42 (β = −6.51 × 10 −4 , p = 3.39 × 10 −6 ), and T-tau/Aβ 42 (β = −5.60 × 10 −3 , p = 2.71 × 10 −6 ), but the positive association with CSF Aβ 42 was at the threshold of significance (β = 6.31, p = 0.059) after controlling for aforementioned covariates ( Figure 2 and Supplemental Table 2A ).
Further to what is listed as major concerns by both reviewers below, (2a) A major concern that arose in the editorial-reviewer discussions is the following: The biperiden effects are either non-significant vs placebo or just at the threshold of significance (SVC) in samples of ~25 per group, so we deem it unlikely that these effects could be very informative at the individual level.