Barely Significant
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“an interesting trend”

1,784 sentences · 1,784 papers · 2,484 search hits before verification · confirmed specimen

Sighted at

p=0.1

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

While our list of variants is not necessarily comprehensive, there is an interesting trend in that nearly all common GOF variants in our list are concentrated toward the 3′-end of the coding region of the LPL gene, with most located in exons 9 and 10, the latter of which encodes the 3′ UTR ( Figure 13 and Supplementary Table S3 ).
We observed an interesting trend in chemical reactivity and stability of the studied compounds to show increasing stability and decreasing reactivity moving from DBPX, DCPX, DFPX to PX and this was obtained from the calculated highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) values.
31 Of note, the phase II MonarcHER trial showed that, in HR-positive/HER2-positive ABC patients, the combination of abemaciclib–fulvestrant–trastuzumab improves mPFS (8.3 months, 95% CI: 5.9-12.6 months) over trastuzumab chemotherapy (5.7 months, 95% CI: 5.4-7.0 months) with hazard ratio of 0.67 (95% CI: 0.45-1.00, P = 0.051), with an interesting trend for improved mOS among patients with luminal versus non-luminal subtypes (31.7 versus 19.7 months, hazard ratio 0.68, 95% CI: 0.46-1.00). 75 Altogether, these trials evidenced the importance of implementing tailored therapeutic options for different patients’ populations.
An interesting trend that was observed in primary human cells, iPSCs, and several mouse organs was that a few AAV variants, such as AAV4 (multiple cell types and tissues, except the lungs), AAV5, and AAV12 (in a few targets, but especially in the case of kidney in the hFRG mouse), were very efficient at cell entry, but were unable to express the transgene at the RNA level.