“an increasing trend”

During the establishment of the type 2 diabetes mellitus rat model, the total serum cholesterol and triglyceride of the rats demonstrated an increasing trend ( P < 0.01).

The overall mortality trend remained stable from 1999 to 2019 (AAPC: −0.09, 95% CI: −0.89 to 0.98), with an increasing trend in AAMRs from 1999 to 2006 (APC: 3.87, 95% CI: 1.15–9.68) ( P = 0.01), followed by a substantial decrease from 2006 to 2009 (APC: −18.95, 95% CI: −23.57 to −8.84) ( P = 0.0004), and a noticeable increase from 2009 to 2019 (APC: 3.52, 95% CI: 1.60–6.99) ( P = 0.001) (Graphical Abstract, Supplemental Digital Content 1, https://links.lww.com/CAEN/A70 ).

And a nonlinear dose-response relationship with an increasing trend between PM 2.5 exposure levels and the risk of PTB recurrence ( P < .01), while a linear dose-response relationship exists between greenness exposure levels and the risk of PTB recurrence ( P = .082) in Fig. 2 .

In contrast, the apoptosis rate of A549 and SK-MES-1 cells presented an increasing trend after overexpression of CBX7 ( p < 0.01) ( Figure 2(b) ).

In the CG, only the BB of both sides showed an increasing trend, while the other muscles remained the same or with a decreasing trend; thus, the difference among the muscles remained highly significant ( p < 0.01) after the intervention, with the consequent slight decrease in total activity (g = 0.01) previously mentioned. 2.2.

An association was found between high paternal exposure to crystalline silica and ALL (OR: 2.20, 95% CI 1.60–3.01), with an increasing trend from no exposure to high exposure ( p =< 0.01) to LMA (OR: 2.03, 95% CI: 1.04–3.97; P for trend: 0.008).

An increasing trend in shared Bacteroides ASVs was observed comparing older vs. younger children (with maternal fecal microbiota: p < 0.01 in the RESONANCE cohort, p > 0.05 in the VDAART cohort; with maternal vaginal microbiota: p > 0.05 in the WISC cohort; Figures S10 A0 and B0).

Under the deforestation since the 1970s, Amazon (15°S–0°, 40°W–80°W) surface air temperature has exhibited an increasing trend (0.26 °C per decade, p < 0.01), while precipitation has shown a decreasing trend (−0.15 mm day −1 per decade, p < 0.01, Fig. 1b , Supplementary Fig. 1 ).

Year of HIV diagnosis was significantly associated with delayed ART initiation ( p <0.01), and there was an increasing trend of ART timely initiation since 2014 (trend χ 2 = 10.514, p <0.01, Figure 2 ).

Additionally, there was an increasing trend in Moran’s I value over time, peaking at 0.41 ( P < 0.01) in 2015–2022, suggesting a growing degree of spatial clustering in incidence rates (Table 1 ).

However, the HDRS scores at T2 showed an increasing trend compared to the T1 scores (Wilcoxon test, Z = −3.504, P < .01). 3.3.

While the proportion of BCLC-B showed a slight decline, BCLC-C, which represents a more advanced stage, demonstrated an increasing trend (p < 0.01, Cochran–Armitage test).

An increasing trend was observed in EMS activation time ( p < 0.01) and pre-hospital time ( p < 0.01) year by year, while the response time time fluctuated within a narrow range without significant changes( p = 0.45).

Compared with the model group, the spleen index of all the experimental groups increased to some extent, but only the APS group and EAF low-dose group displayed statistical differences (p < 0.01), thymus index of all the experimental groups showed an increasing trend, but only the APS group had statistical differences (p < 0.01).

There was an increasing trend of having missing teeth ( p = 0.03) as people aged and a decreasing trend in the number of filled teeth ( p < 0.01).

The overall proportion of treated with antibiotics for patients <5 years age ( p < 0.01), 18–49 years age ( p < 0.01), 50–64 years age ( p < 0.01) and ≥65 years age ( p < 0.01) in emergency departments showed an increasing trend over time, which was similar with he overall proportion of treated with antibiotics for all age group of patients in inpatient departments ( p < 0.01) ( Table 5 ).

N-cadherin showed an increasing trend in the model group, was significantly reduced by PCN (P < 0.01), slightly decreased in PAL, and significantly suppressed in PAH (P < 0.05), also in a dose-dependent manner ( Figure 6C ).

Furthermore, in 2009, 2012 and 2018, the percentage of drugs prescribed from the essential medicine list was 66.50%, 78.50% and 80.34%, respectively, and the percentage of drugs prescribed using generic names was 61.29%, 70.90% and 70.65%, respectively, all of which initially showed an increasing trend and then stabilised (p<0.01) ( table 3 ).

We have found that there was an increasing trend in the number of performed thyroid ultrasounds (p=0.01).

A decreasing trend was observed for keratoleukoma ( P < 0.01) and an increasing trend for corneal endothelial dysfunction ( P < 0.01), regraft ( P = 0.012), corneal limbal dermoids ( P < 0.01) and congenital corneal opacity ( P < 0.01).

The fluorescent images in Figure 3 showed that macrophagocyte in MSN@IL-4 group displayed a decrease of CD86 expression compared to that in control group (0.01 < ∗ p < 0.05); oppositely, CD206 expression displayed an increasing trend in cells subjected to MSN@IL-4 nanomaterial compared to that in the control group (0.001 < ∗∗ p < 0.01).

The proportion of esotropia surgeries showed a decreasing trend from 2016 to 2020 (χ 2 = 31.95, P < 0.01), while the proportion of exotropia surgeries showed an increasing trend over time, but this was not significant ( P = 0.109) (Table 2 ).

MN and MCD presented an increasing trend, of which MN was divided into two segments (2005–2011: APC, 25.8%; 95% CI, 6.3–48.7; p = 0.01; 2011–2020: APC, 3.7%; 95% CI, –5.3 to 13.5; p = 0.40).

Results 76,873 patients were diagnosed with GBC with decreasing incidence rates in all races/ethnicities except NHB who experienced an increasing trend between 2001 and 2014 (APC = 2.08, p < 0.01) and plateauing afterward (APC = −1.21, p = 0.31); (AAPC = 1.03, p = 0.03).

In the unadjusted analyses, there was an increasing trend in the annual rate of NF cases over time (1.9 cases/year, 95% CI: 0.7 to 3.1; p < 0.01; R 2 = 0.60; Fig. 3 A).