Barely Significant
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“an increasing trend”

63,972 sentences · 63,972 papers · 107,686 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

As bite force exhibited an increasing trend with age, commencing from childhood, within the scope of one study, the mean force values required to induce fracture in a 3D-printed resin crown were >1262.5 N for the resin NextDent variant.
The prevalence of COPD demonstrated an increasing trend from 1990 to 2021 in both the 20–54 years age group (rising from 1111.39 to 1190.62 per 100,000 individuals) and the age group over 55 years (increasing from 10,203.61 to 10,477.36 per 100,000 individuals), with AAPCs of 0.23 and 0.09, respectively.
These findings suggest that improvements in healthcare and risk factor management have mitigated the rates, but the rising absolute burden highlights the impact of population growth and aging (Tables 3 , 4 ). Sex-specific burden The estimated annual percentage change (EAPC) was used to quantify temporal trends; a negative EAPC indicates a decreasing rate over time, whereas a positive EAPC represents an increasing trend.
Statistical analysis revealed that from Q1 of 2004 to Q1 of 2025, hematological AEs accounted for 3.73% of all ICI reports, this proportion is slightly higher than the results of previous studies: multiple large-scale retrospective studies have shown that hem-irAEs constitute 0.6%-3.6% of all irAEs [ 15 ], Notably, the proportion demonstrated an increasing trend during 2011 to 2024 (Fig. 3 ).This trend may be attributed to two factors.
NfL concentrations showed a marked increase in AD-dem patients compared to all groups and in MCI compared to CTRL, particularly in the mdMCI condition, showing an increasing trend that reflects the sensitivity of plasma NfL to correlate with the ongoing neuronal degeneration, although in our cohorts NfL was not effective in discriminating individuals in the presymptomatic and prodromal stages [ 56 , 57 ] (Fig. 1 a and Supplementary Fig. 3, see main text and Additional file 2).