Barely Significant
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“an increasing trend”

63,972 sentences · 63,972 papers · 107,686 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Research foundations and emerging trends Research foundations The study of ASR of bone cancer from 1993 to 2012 underscores significant demographic and regional variations, with a notable prevalence in males and an increasing trend in the 60 + age group across diverse regions such as Europe, Asia, North America, and others.
For molecules with novel and complex MOA (e.g., ADCs, TCEs), there is an increasing trend for these molecules to adopt multiscale mechanistic QSP models to support dosage selection. 18 , 24 These models play a pivotal role in guiding data‐driven dose decisions throughout development, from first‐in‐human starting doses to expansion doses and recommended Phase II/III doses.
240 Secondly, there is now an increasing trend toward using short-term survival endpoints such as PFS as surrogates for drug efficacy assessment, but this is a double-edged sword. 456 The advantage is that it accelerates drug approval and reduces development costs, but critics argue that there is no inherent link between PFS and OS determination, and that tumors may later accelerate growth due to resistance, making up for previous deficits.
Advances in molecular pathology and therapy of non-small cell lung cancer.
Signal Transduct Target Ther · 2025 · PMC12167388