Barely Significant
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“an increasing trend”

63,972 sentences · 63,972 papers · 107,686 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Contrasting with the findings of Vargas Trujillo et al., who reported an increasing trend in both median age at diagnosis (from 7.1 years pre-pandemic, to 7.35 during the pandemic, and 8.01 post-pandemic) and bone age (from 9.5 to 10.4 years) ( 46 ), our data reveal a progressive decrease in median age at CPP diagnosis across the three periods (from 8.85 years pre-pandemic, to 8.15 during the pandemic, and 7.98 post-pandemic).
With increasing age, the activity of B cell receptor signaling pathway and B cell activation involved in immune response significantly increased, while the activity of T cell receptor signaling pathway significantly decreased ( P < 0.05); Th1, Th2 and Th17 cell differentiation pathways showed an increasing trend.
This value indicates the annual increase or decrease, with negative values ​​indicating a decreasing trend and positive values indicating an increasing trend [ 26 , 27 ].