Barely Significant
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“a trend toward significance”

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In the literature

Contrariwise, when the effect of CST-IT was evaluated in a sample of VaD patients only ( Piras et al., 2017 ), general cognitive functioning improved at program completion (with a trend toward significance for working memory abilities), but no positive impact was observable on mood and behavior, suggesting that different mechanisms of change are at play when patients with a prominent vascular contribution to dementia are considered.
In the PIONEER 6 trial (which was designed to rule out an excess in cardiovascular risk with oral semaglutide among patients with T2D and not powered to demonstrate superiority), oral semaglutide demonstrated cardiovascular safety compared with placebo, and although there was a trend toward significance for benefit (eg, a 21% risk reduction), statistical significance was not met [43] .
Using a linear model adjusting for age, sex, interval between vaccination and sampling, first vaccine, study and self-reported ethnicity, there was a significant difference in spike antibody levels observed for all individuals when testing the effect of HLA-DQB1*06 accounting for DRB1-71E/R ( P LRT = 5.2 × 10 −3 using the LRT to compare with the null) and for those individuals primed with BNT162b2 ( P LRT = 0.02), with a trend toward significance for individuals primed with ChAdOx1 nCoV-19 ( P LRT = 0.1).