“a strong trend”

[ 48 ] demonstrated that beneficial effects SGLT-2 inhibitors were robust in HF patients regardless of T2DM status, and a strong trend to be effective in HF with preserved EF.

Analysis of the ZT2 versus ZT14 biopsies confirmed significant differences for COL1A2 and COL5A1 , and a strong trend for time‐dependent differences was observed for COL1A1 and MMP14 , the latter of which is required for the release of newly assembled collagen fibrils from the cell (Taylor et al., 2015 ) ( n = 5; Fig.

Although after adjustment for sex, GA, birth weight, and growth restriction, GA (aOR = 0.67; p = 0.068, 95% CI [0.44, 1.03]) and writhing GMs (aOR = 1.44; p = 0.087, 95% CI [0.95, 2.20]) were not significant, a strong trend still persisted.

Effect of Correction of the Extra-ocular Muscle (SMP) Artefact In both cohorts there was a strong trend towards a very small reduction in the mean, over all time-points, of the left and right central 65–85 Hz amplitude after the SMP artefact reduction process (group 1: 0.14 % = 2.6 nV, p = 0.057; group 2: 0.2 % = 3.0 nV, p = 0.076).

Comparing ESI at both the 50% of the spike slope and at the peak of the spike, a strong trend of larger distances was observed between both ESI solutions in patients with less good outcome.

When analyzed by fungal family, Diaporthaceae , Glomerellaceae , and Pestalotiopsidaceae each had over 800 viral taxa and showed a strong trend toward reaching an asymptote.

However, in mature control neurons, we saw a strong trend toward increased activation of caspase-3 post- H 2 O 2 treatment, suggesting a potential induction of caspase-3 activation.

A strong trend from the results was that the prevalence of CRF01_AE and CRF07_BC increased, whereas the prevalence of subtype B/B’ decreased, and the prevalence of CRF07_BC and CRF08_BC has outstripped that of B/B’ after 2010.

While digital technology continues to achieve innovative breakthroughs of its own, it also deeply integrates with traditional manufacturing industries, showing a strong trend of digital transformation and innovation.

Specifically, literature from 2025 indicates a strong trend toward using multi-walled carbon nanotubes (MWCNTs) to develop advanced structural parts, particularly for the aerospace sector [ 5 ].

In the library used here focusing on secreted proteins, we have not observed a strong trend to negative fitness scores, but cannot exclude smaller shifts.

A further strength springs from the fact that a strong trend towards the same results was identified in the analysis of the population identified by the algorithm alone.

Furthermore, the mean duration of seizures at the 125 mg/kg dose showed a strong trend to overall increased seizure duration in the HCl group where the mean duration was ten-fold higher in mice administered bupropion HCl compared to equimolar bupropion HBr.

However, the OLZ/VPA group had significantly higher MetS incidence ( P = 0.002) and greater worsening of fasting plasma glucose (FPG; ΔFPG, P < 0.001), triglycerides (ΔTG, P = 0.033), and blood pressure (ΔSBP, P = 0.065; ΔDBP, P = 0.052), with the changes in blood pressure showing a strong trend towards significance.

Likewise, above borderline mood disorder, and scoring in the upper quartile of the DEX function scale, although the latter with only a strong trend ( table 6 ).

The levels of AEA, PEA and OEA also showed a strong trend in the same direction despite less robust alterations in the expression of genes encoding their metabolising enzymes (Figures 2 and 3 ).

The values do show a strong trend for different flow rates, but do not react so strongly due to the manipulations.

A strong trend emerged toward using predicted epitopes for antivenom development, with multiple studies demonstrating partial or complete neutralization of venom effects in preclinical models.

First generation dams also had lower levels of OT in the amygdala (McMurray et al., 2008a ), but in contrast to their dams, only a strong trend for increased mRNA was found in the supraoptic nucleus (McMurray et al., 2008b ).

Controversy came up with the VA-NEPHRON-D trial that showed a strong trend to lowering the risk of renal disease progression with dual RAAS blockade vs. monotherapy ( 40 ).

Results There was a strong trend of decreasing risk of CP with additional education of both the mother and the father.

Such a strong trend suggests that production anomalies that relate to area changes are not induced by weather conditions (and the LWL issued).

Although a strong trend toward improved survival was also observed for the Concurrent group compared to the RT-first group (aHR = 0.58; 95% CI, 0.37–0.92; P’ = 0.022), this difference did not meet the significance threshold after Bonferroni correction ( Table 3 ).

A meta-analysis of studies in patients with acute stroke receiving intravenous and oral pentoxifylline revealed a strong trend toward reduction in early mortality [ 66 ].

Importantly, there was a strong trend suggesting an interaction between MRD status and benefit from allo-HSCT in first remission.