“a strong trend”

Third, there is a strong trend to switch from monotherapy of benzodiazepines in 2000 to combined hypnotic medication treatment in 2010, along with reduction in benzodiazepine usage and increase in Z drugs usage.

Lastly, we found no difference in thrombus CXCR2 positive cells, but a strong trend in CCR2+ cells, with greater nunbers in IL-6 −/− as compared with WT (Supplemental Fig. 7 ).

There was no survival advantage for NAC versus RC alone but in patients with non-muscle invasive disease a strong trend favoring immediate RC was noted despite a downstaging rate of 61% in the NAC group.

The present understanding of dealloying suggests a strong trend for passivation in the form of an MNE-rich ligament surface during dealloying.

HCP mineral soils also released substantial CO 2 but did not show a strong trend in CO 2 and CH 4 release with water content.

There was a strong trend, although not significant (p = 0.321), towards higher acetate levels in the IgM negative group, 102.3 (8.524–262.8) mmol/L compared to IgM positive group, 47.97 (1.349–173.3) mmol/L which was supported by ROC curve analysis (AUC, 0.7556; Fig. 1 A, Supplementary Fig. 2).

Importantly, a high MF signature also revealed a strong trend toward worsened metastasis survival and lung metastasis‐free survival in breast cancer patients with lung metastases (Supplementary Figure S7E ).

Our current data are consistent with these outcomes, in that WP1066 shows a strong trend to inhibit Reg1 in gastric tumours of the gp130 757FF mouse along with IL-6 and IL-11 inhibition.

The performance changes from Race 1 to Race 2 in the current study were significantly different and manifested as a uniform and significant improvement in race times in the HCHO group and a strong trend to performance impairment in the LCHF group, with only one participant recording a faster race outcome in Race 2 following the LCHF adaptation/enhanced CHO availability intervention.

In cancer site stratified analyses, we found a strong trend towards higher rates of digestive organ cancer, breast cancer, skin cancer, urinary tract cancer and cancer of lymphoid and hematopoietic tissue in patients with HDL values < 35 mg/dl as well as a negative association between total cholesterol > 250 mg/dl and respiratory organ as well as urinary tract cancer.

As shown in Figure 2A , these publications were co-authored by 8,818 authors, reflecting a strong trend of academic collaboration, with international collaborations accounting for 11.18%.

Correlations between biomarkers of inflammation/angiogenesis and other clinical and sonographic variables Ultrasound variables SH grade ≥2 correlated with MMP-2 and transforming growth factor beta-1 and showed a strong trend to correlation with bFGF levels (Table 3 ).

Partially replicating the significant age-related difference reported in this previous study, there was a strong trend for younger mothers ( M = 3.19, SD = 2.44) to have lower scores for appropriate mind-related comments than their older counterparts ( M = 4.18, SD = 2.57), t (149) = 1.91, p = .058, d = .40.

In a recent study comparing the C EIT with C DYN in a pediatric cohort of 12 children with pARDS (5 patients with severe ARDS and 7 with moderate ARDS), the authors revealed no significant changes between both methods of global compliance calculation, although the authors found a strong trend towards a better global compliance with the C EIT approach, which still supports the findings of our study [ 27 ].

Given this, it is intriguing that the short-term firing rate of these cells was not increased, although there was a strong trend toward a greater percent of higher frequency cells.

While oversizing was not independently associated with freedom from significant PPM in this analysis, post‐dilatation demonstrated a strong trend toward a protective effect, consistent with a previous report of favorable outcomes following routine post‐dilatation for BEV [ 33 ].

Nevertheless, we could observe a strong trend of over representation for genes coding for membrane receptors (CD93, ZP1, ESAM, protocadherin 17) and paracrine factors (Leptin, angiopoietin 2, VWF) with a range of over expression [2-6.96] corresponding to ALDOC and TCF1 genes respectively.

As can be seen from Figure 3 , clean energy utilization and non-farming income also have a strong trend of synergistic change—an increase in non-agricultural income increases the proportion of clean energy utilization—supporting the empirical evidence presented in Figure 2 .

Using multivariate logistic regression, a statistically significant relation was only found for an elevated admission serum cTnI, however pH also shows a strong trend toward influencing MACE.

Additionally, no significant differences were found in the number of GFAP+ astrocytic processes ( Fig 2D ) or MBP+ cells ( Fig 2G ) between unirradiated and irradiated organoids at either time point, though we did identify a strong trend indicating differences in MBP+ cell counts between 0.5 and 2 Gy irradiated organoids.

The skin improved significantly on the Dermatology Life Quality Index (DLQI), but showed a strong trend towards improvement on the Psoriasis Area and Severity Index (PASI) (Jensen et al . 2013 ).

This study revealed the following important findings: (a) there was a significant difference in the CAG repeat lengths between MBC patients and controls; (b) long CAG repeat lengths were more common in patients than controls and there was a strong trend toward short CAG repeat lengths being more prevalent in controls than in cases; (c) long CAG repeat sequence presented at the T2-4 stage compared with short CAG repeat sequence in MBC patients but did not differ with respect to other clinicopathological features; (d) there was a significant difference by ER and PR status regarding AR expression in the MBC patients; (e) the presence of long CAG repeat sequence and AR-positive expression were associated with shorter survival of MBC patients.

In the present study we observed high prevalence rates of sedentary behaviors and there was a strong trend for increased OW/OB with increased TV viewing time.

Figure 4A and B likewise shows instances in which the sporulation efficiency was higher in one instance under a high dose than under a low dose of UVR, despite a strong trend supporting a dose- and time-dependent effect of UVR in promoting developmental arrest.

Our principal finding is that a selective strategy of reintervention, predominantly with endovascular relining, in appropriately selected patients was associated with superior outcomes, including a strong trend toward reduced mortality and a significantly higher rate of sac stabilization.